Innate and innate-like lymphocytes in immune-mediated glomerular diseases
Cytokines produced by lymphocytes of the innate and adaptive immune system are central regulators of the immune response in homeostasis and immune-mediated diseases. Recent studies have shown that specialized subsets of “innate-like” T cells that display features of both innate and adaptive immunity, as well as different innate lymphocyte populations reside in the kidney, where they contribute to production of cytokines and regulation of the local immune response. However, the contribution of these innate and innate-like lymphocyte populations to kidney injury and repair in immune-mediated glomerular diseases is still incompletely understood. In the proposed project we will investigate the role of innate-like T cell subsets (focusing on MAIT cells) and innate lymphocyte populations (focusing on NK cells) in immune-mediated glomerular diseases. In a hypothesis based approach, we will first use an experimental mouse model of glomerulonephritis to study the function of kidney-resident NK cells and MAIT cells in glomerular inflammation. These studies will be complemented by a systems biology approach, in which we will perform a high dimensional analysis of the molecular interactions of innate and innate-like lymphocytes with renal parenchymal cells in the healthy human kidney and in renal biopsies of glomerulonephritis patients. Selected interaction pathways identified in these unbiased analyses of human kidney samples will then be subjected to functional testing in in vitro co-culture systems with lymphocytes and renal epithelial cells and in the glomerulonephritis model. In summary, our studies will elucidate the role of innate and innate-like lymphocyte subsets in the renal immune response and will thereby pave the way for targeted treatment approaches in patients with immune-mediated glomerular diseases.
Publications
Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner J Immunol. 2022 Apr
Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U B Enk, Fabian Hausmann, Alina Borchers , Milagros N Wong, Hans-Joachim Paust , Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher , Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze Zur-Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer , Nicola Gagliani, Christian F Krebs.Sci Immunol. 2021 Feb
Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep
Becker M, Gnirck AC, Turner JEFront Immunol. 2020 Jan
Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr
Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug
Xiong T, Turner JESemin Immunopathol. 2018 Jul
Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul
Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer J Am Soc Nephrol. 2018 Feb
Turner JEKidney Int. 2017 Jul
Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul
Project Leader
PD. Dr. Jan-Eric Turner
Co-Workers
Dr. Tingting Xiong
Ann-Christin Gnirck
Constantin Rickassel
Madena Attar
Martinistrasse 52
20246 Hamburg, Germany
Tel: +49-40-7410-51557
Fax: +49-40-7410-59036
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Martinistrasse 52
20246 Hamburg, Germany