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SFB 1192: Immune-Mediated Glomerular Diseases -
Basic Concepts and Clinical Implications

SFB 1192

Welcome to SFB 1192 -
Immune-Mediated Glomerular Diseases –

Immune-mediated glomerular diseases encompass a heterogeneous group of disorders that cause inflammation within the glomerulus and other compartments of the kidney. Despite recent important discoveries in this field, the immunopathogenesis of the various forms of immune-mediated glomerular diseases remains to be fully elucidated. However, fundamental to each of these diseases is immune-mediated kidney injury, which consists of a specific immune reaction followed by an effector phase with destructive inflammation and renal injury. Currently, treatment for most patients with immune-mediated glomerular diseases relies on unspecific immunosuppressive agents that are hazardous and only partially effective. Immune-mediated glomerular diseases therefore remain a leading cause of end-stage kidney failure in the Western world. Thus, determined efforts to characterize underlying immunopathologic mechanisms and to translate results of these studies into novel treatment concepts are clearly needed for the development of more efficacious and safer therapies for immune-mediated glomerular diseases in the future.

The SFB represents an interdisciplinary approach, including scientists with strong expertise in clinical and experimental nephrology, basic immunology, pathology/anatomy, and physiology. Using state-of-the-art techniques and animal models, combined with prospective studies in a large cohort of patients, our SFB seeks to define central immunopathogenic mechanisms underlying glomerular diseases. These studies are the basic prerequisite for a paradigm shift away from unspecific treatment options toward a pathogenesis-based, personalized approach in the field of immune-mediated glomerular diseases.

SFB 1192

The Team

Board Members

Participating Institutions



SFB 1192


Autoimmune Kidney Diseases

SFB 1192


Project A

The figure depicts the main focus of and the interactions between the projects of section A of the SFB 1192. The potential pro-inflammatory ...

Project B

This figure illustrates the main topics of and interactions between the projects of section B of the SFB 1192 ...

Project C

A key issue of the Collaborative Research Centre “Immune-Mediated Glomerular Diseases” is the transfer of experimental results ...

Associated working groups

The close cooperation between the various projects is an important feature of the SFB. Another decisive factor is ...

SFB 1192

Hamburger GN Register

For patients

The Hamburg Glomerulonephritis Registry was set up as part of the Collaborative Research Center 1192 (SFB 1192) at the University Medical Center Hamburg-Eppendorf. It is a data- and biobank ...

For referring physicians

In case you have any questions about the Hamburg Glomerulonephritis Registry or you want to help us in the recruitment of patients with glomerulonephritis in the registry, please contact us.

SFB 1192

Research Training Group


One of the main goals of the SFB1192 is to promote the careers of excellent young researchers and medical students. The prerequisite for this goal is the establishment of a well-structured experimental MD thesis program that attracts outstanding medical students and PhD graduate students with a strong interest in basic and clinical research ...


The Research Training Group "Mechanisms of Immune-Mediated Tissue Injury" offers students a structured training program to improve both scientific and interdisciplinary competences.
In addition, the students will set up an individual coaching/mentoring committee to support the progress of the project by providing feedback and suggestions ...


MD students
Medical students can apply after completing the first part of the medical examination or an equivalent internal examination.

The application phase will take place in December / January each year with the deadline of January 31st. ...