Publikationen 2016

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F
Sci Transl Med. 2016 Nov

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.

Christian F Krebs, Hans-Joachim Paust, Sonja Krohn, Tobias Koyro, Silke R Brix, Jan-Hendrik Riedel, Patricia Bartsch, Thorsten Wiech, Catherine Meyer-Schwesinger, Jiabin Huang, Nicole Fischer, Philipp Busch, Hans-Willi Mittrücker, Ulrich Steinhoff, Brigitta Stockinger, Laura Garcia Perez , Ulrich O Wenzel, Matthias Janneck, Oliver M Steinmetz, Nicola Gagliani, Rolf A K Stahl, Samuel Huber, Jan-Eric Turner, Ulf Panzer
Immunity. 2016 Nov

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RAK, Panzer U, Steinmetz OM.
Kidney Int. 2016 Jan

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Science. 2016 Oct

Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss F
J Am Soc Nephrol. 2016 Jul

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. 

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C
J Immunol. 2016 Jul

A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.

Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.
Kidney Int 2016

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO
Am J Physiol Renal Physiol. 2016 Jun

A Mechanism for Cancer-Associated Membranous Nephropathy. 

Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA
N Engl J Med. 2016 May

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C
J Am Soc Nephrol. 2016 Nov

Immune Mechanisms in Arterial Hypertension

Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H
J Am Soc Nephrol. 2016 Mar

RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2016 Feb

The Role of Renal Progenitors in Renal Regeneration

Meyer-Schwesinger C
Nephron. 2016

Stat3 programs Th17-specific regulatory T cells to control GN.

Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2014 Jun

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Nicola Gagliani, Maria Carolina Amezcua Vesely, Andrea Iseppon, Leonie Brockmann, Hao Xu, Noah W Palm, Marcel R de Zoete, Paula Licona-Limón, Ricardo S Paiva, Travers Ching, Casey Weaver, Xiaoyuan Zi, Xinghua Pan, Rong Fan, Lana X Garmire, Matthew J Cotton, Yotam Drier, Bradley Bernstein, Jens Geginat, Brigitta Stockinger, Enric Esplugues, Samuel Huber, Richard A Flavell
Nature. 2015 Jul

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