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Publications

Host DNases prevent vascular occlusion by neutrophil extracellular traps.

Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA
Science. 2017 Dec

Pro-longed IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells.

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges JF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine AK, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.
Cell Rep. 2017 Oct

Natural killers: the bad guys in fibrosis? 

Turner JE
Kidney Int. 2017 Jul

IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JE
J Am Soc Nephrol. 2017 Jul

RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.
Clin Exp Immunol. 2017 Apr

A pathogenic role of complement in arterial hypertension and hypertensive end organ damage.

Wenzel UO, Bode M, Köhl J, Ehmke H
Am J Physiol Heart Circ Physiol. 2017 Mar

Fully automated evaluation of total glomerular num-ber and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Matthias Gunzer
J Am Soc Nephrol. 2017 Feb

T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM
J Am Soc Nephrol. 2017 Jan

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.

Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrucker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RAK, Huber S, Turner JE, Panzer U.
Immunity. 2016 Nov

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F
Sci Transl Med. 2016 Nov

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RAK, Panzer U, Steinmetz OM.
Kidney Int. 2016 Jan

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel Huber
Science. 2016 Oct

Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss F
J Am Soc Nephrol. 2016 Jul

FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. 

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C
J Immunol. 2016 Jul

A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.

Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.
Kidney Int 2016

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UO
Am J Physiol Renal Physiol. 2016 Jun

A Mechanism for Cancer-Associated Membranous Nephropathy. 

Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA
N Engl J Med. 2016 May

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C
J Am Soc Nephrol. 2016 Nov

Immune Mechanisms in Arterial Hypertension

Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H
J Am Soc Nephrol. 2016 Mar

RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.
J Am Soc Nephrol. 2016 Feb