Publications
mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF.
JCI Insight. 2019 Sep
Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.
Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ.
Kidney Int. 2019 Aug
A Novel Role for IL-6 Receptor Classic Signaling: Induction of ROR γ t+Foxp3+ Tregs with Enhanced Suppressive Capacity.
Julia Hagenstein, Simon Melderis, Anna Nosko, Matthias T Warkotsch, Johannes V Richter, Torben Ramcke, Georg R Herrnstadt, Jürgen Scheller, Isabell Yan, Hans-Willi Mittrücker, Malte A Kluger, Oliver M Steinmetz.
J Am Soc Nephrol. 2019 Aug
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Maria Carolina Amezcua Vesely , Paris Pallis, Piotr Bielecki , Jun Siong Low, Jun Zhao, Christian C D Harman, Lina Kroehling, Ruaidhrí Jackson, Will Bailis, Paula Licona-Limón, Hao Xu, Norifumi Iijima, Padmini S Pillai, Daniel H Kaplan, Casey T Weaver, Yuval Kluger, Monika S Kowalczyk, Akiko Iwasaki, Joao P Pereira, Enric Esplugues, Nicola Gagliani, Richard A Flavell Cell. 2019 Aug
Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies
Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel & Christine Skerka
Nat Commun. 2019 Jul
C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.
Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C.
Front Immunol. 2019 May
Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.
Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB
Cell Rep. 2019 Apr
The Ubiquitin Proteasome System in Kidney Physiology and Disease.
Meyer-Schwesinger C
Nat Rev Nephrol. 2019 Apr
Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.
Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin Neumann
Am Soc Nephrol. 2023 Mar
Thrombospondin Type 1 Domain-Containing 7A (THSD7A) Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.
Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C
J Am Soc Nephrol. 2019 Apr
Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.
Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JE
Am J Physiol Renal Physiol. 2019 Apr
ApoE attenuates unresolvable inflammation by complex formation with activated C1q.
Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR*
Nat Med. 2019 Mar
*equal contribution
C3 Glomerulopathy-Understanding a Rare Complement-Driven Renal Disease.
Smith RJH, Appel G, Blom AM, Cook HT, D’Agati V, Fakhouri F, Véronique Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris J, Noris M, Pickering MC, Remuzzi G, Santiago Rodriguez de Córdoba S, Sethi S, Van der Vlag J, Zipfel PF, Nester CM
Nat Rev Nephrol. 2019 Mar
Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke, AT, Laban, K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch CP, Duncan KE, Saftig P, Rischen MM, Morellini F, Meyer-Schwesinger C
Proc Natl Acad Sci U S A. 2019 Mar
The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.
Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF
Kidney Int. 2019 Feb
The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.
Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G
Sci Rep. 2019 Feb
Purine Release, Metabolism, and Signaling in the Inflammatory Response.
Linden J, Koch-Nolte F, Dahl G.
Annu Rev Immunol. 2019 Jan
DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber T
J Am Soc Nephrol.. 2019 Jan
Immunohistochemical and serological characterization of membranous nephropathy in children and adolescents.
Dettmar AK, Wiech T, Kemper MJ, Soave A, Rink M, Oh J, Stahl RAK, Hoxha E.
Pediatr Nephrol. 2018 Mar
Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.
Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R Izbicki, Ansgar W Lohse, Richard A Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J Villablanca, Nicola Gagliani, Samuel Huber
Nat Commun. 2018 Dec