Publikationen 2022
Tissue-resident memory T cells in the kidney
Asada N, Ginsberg P, Gagliani N, Mittrücker HW, Panzer U.
Semin Immunopathol. 2022 Nov
Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs
Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A Schildberg, Paul A Gleeson, Birgit M Reipert, Johannes Oldenburg, Christian Kurts
J Clin Invest. 2022 Nov
Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy.
Thorsten Wiech, Linda Reinhard, Sonia Wulf, Alfio Edoardo Giuffrida, Elisa Longhitano, Rosario Caruso, Hermann-Josef Gröne, Rolf A K Stahl, Peter F Zipfel, Judith Kikhney, Annette Moter, Elion Hoxha, Domenico Santoro
Lancet. 2022 Nov
A slit-diaphragm-associated protein network for dynamic control of renal filtration.
Maciej K Kocylowski, Hande Aypek, Wolfgang Bildl, Martin Helmstädter, Philipp Trachte, Bernhard Dumoulin, Sina Wittösch, Lukas Kühne, Ute Aukschun, Carolin Teetzen, Oliver Kretz, Botond Gaal, Akos Kulik, Corinne Antignac, Geraldine Mollet, Anna Köttgen, Burulca Göcmen, Jochen Schwenk, Uwe Schulte, Tobias B Huber, Bernd Fakler, Florian Grahammer
Nat Commun. 2022 Oct
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M C Böhner, Dennis Huugen, Carina C de Oliveira Mann, Simon Otten, Stefanie A I Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A Lyons, Peter Boor, Angela Rösen-Wolff, Lino L Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
J Exp Med. 2022 Oct
Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy.
Linda Reinhard, Maya Machalitza, Thorsten Wiech, Hermann-Josef Gröne, Moritz Lassé, Markus M Rinschen, Nicoletta Ferru, Jan Hinrich Bräsen, Friederike Drömann, Peter Maria Rob, Sanjeev Sethi, Elion Hoxha, Rolf A K Stahl
J Am Soc Nephrol. 2022 Oct
Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice
Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.
Kidney Int. 2022 Sep
Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.
Ermanila Dhana, Daniela Klaus, Alexander Böhner, Florian Schmidt, Sibylle von Vietinghoff, Peter Boor, Sonja Djudjaj, Christian Kurts
J Immunol Methods. 2022 Aug
Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis
Linke A, Tiegs G, Neumann K.
Cells. 2022 May
The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses.
Simon Melderis, Matthias T Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R Herrnstadt, Christoph B Niehus, Frederic C Feindt, Dominik Kylies, Victor G Puelles, Carmen Berasain, Matias A Avila, Katrin Neumann, Gisa Tiegs, Tobias B Huber, Pierre-Louis Tharaux, Oliver M Steinmetz.
J Autoimmun 2022 May
Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy
Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F.
J Clin Invest. 2022 May
Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.
Cells. 2022 Apr
Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis.
Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner
J Immunol. 2022 Apr
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.
Bartsch P, Kilian C, Hellmig M, Paust HJ, Borchers A, Sivayoganathan V, Enk L, Zhao Y, Shaikh N, Büttner H, Wong MN, Puelles VG, Wiech T, Flavell R, Huber TB, Turner JE, Bonn S, Huber H, Gagliani N, Mittrücker HW, Rohde H, Panzer U, Krebs CF.
PLoS Pathog. 2022 Apr
Membranous nephropathy: new pathogenic mechanisms and their clinical implications.
Elion Hoxha, Linda Reinhard, Rolf A K Stahl
Nat Rev Nephrol. 2022 Apr
Molecular consequences of SARS-CoV-2 liver tropism
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB.
Nat Metab. 2022 Mar
Across scales: novel insights into kidney health and disease by structural biology.
Nicola M Tomas, Simon A Mortensen, Matthias Wilmanns, Tobias B Huber
Kidney Int. 2021 Apr