• Studium der Medizin an der Universität Hamburg
• Promotion (Dr. Med) in der Medizinische Kernklinik am UKE
• Assistenzarzt in der III. Medizinischen Klinik am UKE
• Aufbaustudium „Molekularbiologie“ am Zentrum für Molekulare Neurobiologie Hamburg
• Forschungsstipendium der DFG am Institute for
• Research in Biomedicine in Bellinzona, Schweiz
• Facharzt für Innere Medizin und Facharzt für Nephrologie
• Habilitation in der Inneren Medizin, Universität Hamburg
• Leiter der Klinischen Forschungsgruppe 228 “Immunopathogenesis of GN”
• W3 Professur in der III. Medizinischen Klinik am UKE
• Co-Sprecher des SFB1192
• Leiter der Sektion Translationale Immunologie am UKE

• Franz-Volhard-Preis der Deutschen Gesellschaft für Nephrologie

• CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.

  Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O Wenzel, Oliver M Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T Lindenmeyer, Elion Hoxha, Rolf A K Stahl, Tobias B Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F Krebs, Ulf PanzerSci Transl Med. 2023 Mar

• Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.

  Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M Tomas, Elion Hoxha, Ulrich O Wenzel, Tobias B Huber, Thorsten Wiech, Jan-Eric Turner, Christian F Krebs, Ulf PanzerJCI Insight. 2023 Jan

• Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

  Bertram T, Reimers D, Lory NC, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt MV, Bono MR, Gagliani N, Sandrock I, Panzer U, Krebs CF, Meyer-Schwesinger C, Prinz I, Mittrücker HWProc Natl Acad Sci U S A. 2023 Jan

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.

  Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U.J Am Soc Nephrol. 2021 Dec

• Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis.

  Brede KM, Schmid J, Steinmetz OM, Panzer U, Klinge S, Mittrücker HW.Immuno Lett. 2021 Aug

• Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.

  Krebs CF, Tuner JE, Riedel JH, Panzer UJ Clin Invest. 2021 Jun

• A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood.

  Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F Krebs, Sarina Ravens, Immo Prinz Sci Immunol. 2021 Apr

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

  Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U B Enk, Fabian Hausmann, Alina Borchers , Milagros N Wong, Hans-Joachim Paust , Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher , Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze Zur-Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer , Nicola Gagliani, Christian F Krebs.Sci Immunol. 2021 Feb

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.

  Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.Sci Immunol. 2020 Aug

• Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 Immunity.

  Adrian Schreiber, Anthony Rousselle, Jan Klocke, Sebastian Bachmann, Suncica Popovic, Julia Bontscho, Kai M Schmidt-Ott, Volker Siffrin, Uwe Jerke, Muhammad Imtiaz Ashraf, Ulf Panzer, Ralph KettritzJ Am Soc Nephrol. 2020 Jul

• Kidney dendritic cells: fundamental biology and functional roles in health and disease.

  Kurts C, Ginhoux F, Panzer UNat Rev Nephrol. 2020 Jul

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

  Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• Tissue-Resident Lymphocytes in the Kidney.

  Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer J Am Soc Nephrol. 2018 Feb

• Host DNases prevent vascular occlusion by neutrophil extracellular traps.

  Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TAScience. 2017 Dec

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.

  Christian F Krebs, Hans-Joachim Paust, Sonja Krohn, Tobias Koyro, Silke R Brix, Jan-Hendrik Riedel, Patricia Bartsch, Thorsten Wiech, Catherine Meyer-Schwesinger, Jiabin Huang, Nicole Fischer, Philipp Busch, Hans-Willi Mittrücker, Ulrich Steinhoff, Brigitta Stockinger, Laura Garcia Perez , Ulrich O Wenzel, Matthias Janneck, Oliver M Steinmetz, Nicola Gagliani, Rolf A K Stahl, Samuel Huber, Jan-Eric Turner, Ulf PanzerImmunity. 2016 Nov

• Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

  Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

  Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN
  Disteldorf E, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RAK, Kurts C, Kaufmann SHE, Panzer U.
  J Am Soc Nephrol. 2015

• The immune system and kidney disease: basic concepts and clinical implications.
  Kurts C*, Panzer U*, Anders HJ, Rees AJ*contributed equally
  Nat Rev Immunol. 2013

• Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
  Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2013

• Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
  Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
  J Am Soc Nephrol. 2012

• The IL-23 / Th17 axis contributes to renal tissue damage in experimental glomerulonephritis.
  Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker HW, Stahl RA, Panzer U
  J Am Soc Nephrol. 2009

• Studium der Chemie an der Unviersität Frankfurt/Main
• Studium der Biochemie an der Universität Tübingen
• Promotion (Dr. rer. nat.) am Institut für Physiologische Chemie, Universität Tübingen
• Wissenschaftliche Mitarbeiterin in der Abteilung für Biochemische Pharmakologie, Universität Konstanz
• Habilitation in Pharmakologie und Toxikologie, Universität Konstanz
• Professur für Experimentelle Toxikologie am Institut für Experimentelle und Klinische Pharmakologie der Medizinischen Fakultät der Universität Erlangen-Nürnberg
• Professur und Leitung des Instituts für Experimentelle Immunologie und Hepatologie, UKE
• Leitung der Pharmakologie und Toxikologie an der Universität Regensburg, abgelehnt

• Hans Popper “Förderpreis” für die beste experimentelle Arbeit mit klinischem Bezug auf dem Gebiet der Hepatologie
• Sandoz-Preis für therapierelevante pharmakologische Forschung

• Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis

  Linke A, Tiegs G, Neumann K. Cells. 2022 May

• Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells

  Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.Cells. 2022 Apr

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver.
  Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K, Sass G, Tiegs G
  Sci Rep. 2019

• Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.
  Horst AK*, Wegscheid C*, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G
  Hepatology. 2018

• A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis.
  Neumann K*, Karimi K*, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
  J Immunol. 2017

• Regulatory T cell-derived interleukin-10 ameliorates crescentic glomerulonephritis.
  Ostmann A, Paust HJ, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell RA, Erhardt A, Tiegs G
  J Am Soc Nephrol. 2013

• Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells.
  Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
  J Immunol. 2013

• Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
  Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G.
  Kidney Int. 2011

• CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
  Erhardt A, Wegscheid C, Claass B, Carambia A, Herkel J, Mittrücker HW, Panzer U, Tiegs G
  J Immunol. 2011

• Autonomic renal denervation ameliorates experimental GN.
  Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G
  J Am Soc Nephrol. 2008

• Studium der Biochemie an der Universität Potsdam
• Promotion an der Medizinischen Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité - Universitätsmedizin Berlin
• Wissenschaftliche Mitarbeiterin in der Medizinischen Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin
• Wissenschaftliche Mitarbeiterin am Institut für Experimentelle Immunologie und Hepatologie, Universitätsklinikum Hamburg-Eppendorf

• Pathogenic T-Cell Responses in Immune-Mediated Glomerulonephritis

  Linke A, Tiegs G, Neumann K. Cells. 2022 May

• Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells

  Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.Cells. 2022 Apr

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G Sci Rep. 2019 Feb

• Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.
  Breda PC, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber TB, Panzer U, Tiegs G, Neumann K
  Am J Physiol Renal Physiol. 2019 Apr
  
  
• The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.
  Neumann K, Ostmann A, Breda PC, Ochel A, Tacke F, Paust HJ, Panzer U, Tiegs G
  Sci Rep 2019 Feb
• Interferon-g-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.
  Ravichandran G*, Neumann K*, Berkhout L, Weidemann S, Langeneckert AE, Schwinge D, Poch T, Huber S, Schiller B, Hess LU, Ziegler AE, Oldhafer KJ, Barikbin B, Schramm C, Altfeld M, Tiegs G
  J Hepatol 2019 Jun
• Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver.
  Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K, Sass G, Tiegs G
  Sci Rep 2019 Mar
• CEACAM1 controls IL-2-dependent regulatory T cell induction in immune-mediated hepatitis.
  Horst AK, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert AE, Oldhafer KJ, Weiler-Normann C, Lang KS, Singer BB, Altfeld M, Diehl L, Tiegs G
  Hepatology 2018 Jul
• A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis.
  Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
  J Immunol 2017 Jan
• Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway.
  Neumann K, Rudolph C, Neumann C, Janke M, Amsen D, Scheffold A
  Eur J Immunol. 2015 Jul
• Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver.
  Neumann K, Erben U, Kruse N, Wechsung K, Schumann M, Klugewitz K, Scheffold A, Kühl AA
  PLoS One. 2015 Jun
• Role of Blimp-1 in programing Th effector cells into IL-10 producers.
  Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A
  J Exp Med. 2014 Aug
• Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid.
  Neumann K, Kruse N, Szilagyi B, Erben U, Rudolph C, Flach A, Zeitz M, Hamann A, Klugewitz K
  Hepatology. 2012 Jun

• Studium der Medizin an der Universität Köln und Universität Hamburg
• Promotion (Dr. med.) im Zentrum für Molekulare Neurobiologie Hamburg (ZMNH)
• Assistenzarzt in der III. Medizinischen Klinik, UKE
• Postdoc am Centre for Inflammatory Diseases, Monash, Australia
• Facharzt für Innere Medizin und Nephrologie
• Habilitation in Innere Medizin an der Universität Hamburg
• Oberarzt in der III. Medizinische Klinik, UKE
• aPL Professur

• Hans-U.-Zollinger-Forschungspreis der DGfN (2015)
• Dr.-Liselotte-Brauns-Preis für Innere Medizin der Liselotte-Brauns Stiftung (2015)

• The CCR6/CCL20 axis expands RORγt+ Tregs to protect from glomerulonephritis.

  Georg R Herrnstadt, Christoph B Niehus, Torben Ramcke , Julia Hagenstein, Laura-Isabell Ehnold, Anna Nosko, Matthias T Warkotsch, Frederic C Feindt, Simon Melderis, Hans-Joachim Paust, Varshi Sivayoganathan, Saskia-Larissa Jauch-Speer, Milagros N Wong, Daniela Indenbirken, Christian F Krebs, Tobias B Huber, Ulf Panzer, Victor G Puelles, Malte A Kluger, Oliver M Steinmetz.Kidney Int. 2023 Mar

• The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses.

  Simon Melderis, Matthias T Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R Herrnstadt, Christoph B Niehus, Frederic C Feindt, Dominik Kylies, Victor G Puelles, Carmen Berasain, Matias A Avila, Katrin Neumann, Gisa Tiegs, Tobias B Huber, Pierre-Louis Tharaux, Oliver M Steinmetz.J Autoimmun 2022 May

• Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells

  Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.Cells. 2022 Apr

• Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells.

  Melderis S, Hagenstein J, Warkotsch MT, Dang J, Herrnstadt GR, Niehus CB, Neumann K, Panzer U, Berasain C, Avila MA, Tharaux PL, Tiegs G, Steinmetz OM.J Am Soc Nephrol. 2020 Sep

• A Novel Role for IL-6 Receptor Classic Signaling: Induction of ROR γ t+Foxp3+ Tregs with Enhanced Suppressive Capacity.

  Julia Hagenstein, Simon Melderis, Anna Nosko, Matthias T Warkotsch, Johannes V Richter, Torben Ramcke, Georg R Herrnstadt, Jürgen Scheller, Isabell Yan, Hans-Willi Mittrücker, Malte A Kluger, Oliver M Steinmetz.J Am Soc Nephrol. 2019 Aug

• IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. 

  Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OM.J Am Soc Nephrol. 2018 Jul

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RAK, Panzer U, Steinmetz OM.Kidney Int. 2016 Jan

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
  Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  Kidney Int. 2016
  
  
• RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
  Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  J Am Soc Nephrol. 2016
  
  
• Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN.
  Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RAK, Panzer U, Steinmetz OM:
  J Am Soc Nephrol. 2015
  
  
• Stat3 Programs Th17-Specific Regulatory T Cells to Control GN.
  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix S, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM
  J Am Soc Nephrol. 2014

• B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis.
  Kluger MA, Ostmann A, Luig M, Meyer MC, Goerke B, Paust HJ, Meyer-Schwesinger C, Stahl RA, Panzer U, Tiegs G, Steinmetz OM
  Eur J Immunol. 2014
  
  
• Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
  Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
  Nat Immunol. 2013
  
  
• The Th17-defining transcription factor RORγt promotes glomerulonephritis.
  Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR
  J Am Soc Nephrol. 2011

• Studium der Biologie an der Universität Mainz
• Promotion (Dr. rer. nat.) in der 1. Medizinischen Klinik, Sektion Pathophysiologie, Universität Mainz
• Postdoc in der Abteilung Immunolgie am Bernhard-Nocht-Institute für Tropenmedizin, Hamburg
• Postdoc am Ontario Cancer Institute, Toronto, Canada
• Arbeitsgruppenleiter in der Abteilung Immunologie am Max-Planck-Institute für Infektionsbiologie, Berlin
• Habilitation in Immunologie und Medizinischer Mikrobiologie an der Freien Universität Berlin
• W2 Professur am Institut für Immunologie, UKE Hamburg

• Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

  Bertram T, Reimers D, Lory NC, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt MV, Bono MR, Gagliani N, Sandrock I, Panzer U, Krebs CF, Meyer-Schwesinger C, Prinz I, Mittrücker HWProc Natl Acad Sci U S A. 2023 Jan

• Tissue-resident memory T cells in the kidney

  Asada N, Ginsberg P, Gagliani N, Mittrücker HW, Panzer U.Semin Immunopathol. 2022 Nov

• Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.

  Bartsch P, Kilian C, Hellmig M, Paust HJ, Borchers A, Sivayoganathan V, Enk L, Zhao Y, Shaikh N, Büttner H, Wong MN, Puelles VG, Wiech T, Flavell R, Huber TB, Turner JE, Bonn S, Huber H, Gagliani N, Mittrücker HW, Rohde H, Panzer U, Krebs CF.PLoS Pathog. 2022 Apr

• Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis.

  Brede KM, Schmid J, Steinmetz OM, Panzer U, Klinge S, Mittrücker HW.Immuno Lett. 2021 Aug

• Rituximab Induces Complete Remission of Proteinuria in a Patient With Minimal Change Disease and No Detectable B Cells

  Webendörfer M, Reinhard L, Stahl RAK, Wiech T, Mittrücker HW, Harendza S, Hoxha E.Front Immunol. 2021 Feb

• Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.

  Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.Sci Immunol. 2020 Aug

• Tissue-Resident Lymphocytes in the Kidney.

  Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer J Am Soc Nephrol. 2018 Feb

• Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism.
  Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker H-W
  Sci Rep. 2016
  
  
• ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses.
  Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker H-W*, Chalaris A*. *contributed equally
  J Leukoc Biol. 2016
  
  
• CXCR3+ regulatory T cells control TH1 responses in crescentic GN.
  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
  J Am Soc Nephrol. 2016
  
  
• TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis.
  Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker H-W (2015).
  J Pathol. 2015
  
  
• Glomerulopathy induced by immunization with a peptide derived from the Goodpasture antigen α3IV-NC1.
  Hopfer H, Hünemörder S, Treder J, Turner J-E, Paust H-J, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H-W (2015).
  J Immunol. 2015
  
  
• CXCL5 drives neutrophil recruitment in TH17-mediated GN.
  Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
  J Am Soc Nephrol. 2015
  
  
• The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
  Raczkowski F, Ritter J, Heesch K, Schumacher V, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker H-W*, Huber M*. (*contributed equally)
  Proc Natl Acad Sci U S A. 2013
  
  
• Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis.
  Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker H-W
  Kidney Int. 2012

• Bachelor-Abschluss in Biotechnologie, University of Milano-Bicocca (IT)
• Master-Abschluss in Medizinischer Biotechnologie, University of Milano-Bicocca (IT)
• Bachelor-Arbeit in Ospedale San Raffaele (IT)
• Master-Arbeit im Beth Israel Deaconess Medical Center, Harvard Medical
School (USA)
• Promotion (Ph.D.) in Molekularer Medizin, Università Vita-Salute San Raffaele (IT)
• Forschungsaufenthalt als Ph.D. Student an der Yale School of Medicine (USA)
• Postdoc-Stipendiat an der Yale School of Medicine, Department of Immunobiology (USA)
• Assistant Professor (25%) für Molekulare Medizin am Karolinska Institute, Stockholm (SE)
• W3 Professur für Gastrointestinale Karzinogenese am Universitätsklinikum Hamburg-Eppendorf

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.

  Schmidt T, Luebbe J, Kilian C, Riedel JH, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell RA, Gagliani N, Pelzcar P, Huber S, Huber TB, Turner JE, Paust HJ, Krebs CF, Panzer U.J Am Soc Nephrol. 2021 Dec

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

  Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U B Enk, Fabian Hausmann, Alina Borchers , Milagros N Wong, Hans-Joachim Paust , Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher , Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze Zur-Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer , Nicola Gagliani, Christian F Krebs.Sci Immunol. 2021 Feb

• Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.

  Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.Sci Immunol. 2020 Aug

• Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.

  Maria Carolina Amezcua Vesely , Paris Pallis, Piotr Bielecki , Jun Siong Low, Jun Zhao, Christian C D Harman, Lina Kroehling, Ruaidhrí Jackson, Will Bailis, Paula Licona-Limón, Hao Xu, Norifumi Iijima, Padmini S Pillai, Daniel H Kaplan, Casey T Weaver, Yuval Kluger, Monika S Kowalczyk, Akiko Iwasaki, Joao P Pereira, Enric Esplugues, Nicola Gagliani, Richard A Flavell Cell. 2019 Aug

• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

  Nicola Gagliani, Maria Carolina Amezcua Vesely, Andrea Iseppon, Leonie Brockmann, Hao Xu, Noah W Palm, Marcel R de Zoete, Paula Licona-Limón, Ricardo S Paiva, Travers Ching, Casey Weaver, Xiaoyuan Zi, Xinghua Pan, Rong Fan, Lana X Garmire, Matthew J Cotton, Yotam Drier, Bradley Bernstein, Jens Geginat, Brigitta Stockinger, Enric Esplugues, Samuel Huber, Richard A Flavell Nature. 2015 Jul

• TH17 cell plasticity: The role of dendritic cells and molecular mechanisms.
  Agalioti T, Villablanca EJ, Huber S, Gagliani N.
  J Autoimmun. 2018
  
  
• Intestinal IFN-γ-producing Tr1-cells co-express CCR5 and PD-1, and down-regulate IL-10 in the inflamed gut of IBD patients.
  Alfen JS*, Larghi P*, Facciotti F*, Gagliani N*, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J.
  J Allergy Clin Immunol. 2018
  
  
• Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.
  Bosurgi L, Cao Y G, Cabeza-Cabrerizo M, Tucci A, Hughes L D, Kong Y, Weinstein J S, Licona-Limon P, Schmid E T, Pelorosso F, Gagliani N, Craft J E, Flavell R A, Ghosh S, Rothlin C V.
  Science. 2017
  
  
• A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
  Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
  Science. 2016
  
  
• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
  Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
  Nature. 2015
  
  
• The Fire Within: Microbes inflame tumor.
  Gagliani N*, Bo H*, Huber S*, Elinav E*, Flavell RA.
  Cell. 2014
  
  
• Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
  Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
  Nat Med. 2013
  
  
• Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
  Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
  Immunity. 2011

• Studium der Medizin an den Universitäten Göttingen und Hamburg
• Promotion (Dr. med.) am Institut für Immunologie, UKE; summa cum laude
• Facharzt für Innere Medizin und Nephrologie
• Forschungsstipendium der Medizinischen Fakultät am UKE
• Stipendium der Deutschen Gesellschaft für Nephrologie und Deutschen Nierenstiftung
• Habilitation in Innere Medizin und Nephrologie an der Universität Hamburg
• Oberarzt in der III. Medizinische Klinik, Sektion Translationale Immunologie, UKE

• Medac-Forschungspreis für Immunologie (Promotion) (2006)
• Adalbert-Buding-Forschungspreis der Deutschen Hochdruckliga (2011)
• Dr.-Martini-Preis der Dr.-Martini-Stiftung in Hamburg (2014)
• Hans-U.-Zollinger-Forschungspreis der DGfN (2017)

• CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.

  Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O Wenzel, Oliver M Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T Lindenmeyer, Elion Hoxha, Rolf A K Stahl, Tobias B Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F Krebs, Ulf PanzerSci Transl Med. 2023 Mar

• Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

  Bertram T, Reimers D, Lory NC, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt MV, Bono MR, Gagliani N, Sandrock I, Panzer U, Krebs CF, Meyer-Schwesinger C, Prinz I, Mittrücker HWProc Natl Acad Sci U S A. 2023 Jan

• Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection.

  Bartsch P, Kilian C, Hellmig M, Paust HJ, Borchers A, Sivayoganathan V, Enk L, Zhao Y, Shaikh N, Büttner H, Wong MN, Puelles VG, Wiech T, Flavell R, Huber TB, Turner JE, Bonn S, Huber H, Gagliani N, Mittrücker HW, Rohde H, Panzer U, Krebs CF.PLoS Pathog. 2022 Apr

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.

  Krebs CF, Tuner JE, Riedel JH, Panzer UJ Clin Invest. 2021 Jun

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.

  Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.Sci Immunol. 2020 Aug

• Drawing a single-cell landscape of the human kidney in (pseudo)-space and time.

  Krebs CF, Schlitzer A, Kurts C.Kidney Int. 2020 May

• Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

  Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R Izbicki, Ansgar W Lohse, Richard A Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J Villablanca, Nicola Gagliani, Samuel HuberNat Commun. 2018 Dec

• Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.

  Christian F Krebs, Hans-Joachim Paust, Sonja Krohn, Tobias Koyro, Silke R Brix, Jan-Hendrik Riedel, Patricia Bartsch, Thorsten Wiech, Catherine Meyer-Schwesinger, Jiabin Huang, Nicole Fischer, Philipp Busch, Hans-Willi Mittrücker, Ulrich Steinhoff, Brigitta Stockinger, Laura Garcia Perez , Ulrich O Wenzel, Matthias Janneck, Oliver M Steinmetz, Nicola Gagliani, Rolf A K Stahl, Samuel Huber, Jan-Eric Turner, Ulf PanzerImmunity. 2016 Nov

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• CXCL5 drives neutrophil recruitment in TH17-mediated GN.
  Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.
  J Am Soc Nephrol. 2015
  
  
• Micro-RNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.
  Krebs CF, Kapffer S, Paust HJ, Schmidt T, Bennstein SB, Peters A, Stege G, Brix SR, Meyer-Schwesinger C, Müller RU, Turner JE, Steinmetz OM, Wolf G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2013
  
  
• Immature renal DC recruit regulatory CXCR6+ iNKT cells to attenuate crescentic GN.
  Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U
  J Am Soc Nephrol. 2012
  
  
• CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
  Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F.
  J Immunol. 2005
  
  
• NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
  Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
  Immunity. 2003

• Studium der Medizin an der Universität Ulm, Heidelberg, und Mainz
• Promotion (Dr. med.) in der I. Medizinische Klinik, Universität Mainz
• Assistenzarzt in der I. Medizinische Klinik, UKE
• Postdoc am Department of Immunobiology, Yale University, School of Medicine
• Leiter einer Forschungsgruppe in der I. Medizinische Klinik, UKE
• Peter Hans Hofschneider Professor (W2) für Molekulare Immunologie und Gastroenterologie in der I. Medizinischen Klinik, UKE
• Oberarzt in der I. Medizinischen Klinik, UKE
• Heisenberg Professor (W3) für Intestinale Immunregulation

• Dr.-Martini-Preis der Dr.-Martini-Stiftung (2009)
• Postdoctoral research fellowship award der
• Crohns and Colitis foundation of America (2011)
• Ernst Jung-Karriere-Förderpreis (2012)
• Dr.-Liselotte-Brauns-Preis der Liselotte-Brauns Stiftung (2013)
• Theodor-Frerichs-Preis der Deutschen Gesellschaft für Innere Medizin (DGIM) (2017)

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.

  Laura Garcia Perez, Jan Kempski, Heather M McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H Guse, Daniel Perez, Jakob R Izbicki, Nicola Gagliani, Richard A Flavell, Samuel HuberNat Commun. 2020 May

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

• Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

  Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R Izbicki, Ansgar W Lohse, Richard A Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J Villablanca, Nicola Gagliani, Samuel HuberNat Commun. 2018 Dec

• A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

  Penelope Pelczar, Mario Witkowski, Laura Garcia Perez, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani, Richard A Flavell, Samuel HuberScience. 2016 Oct

• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

  Nicola Gagliani, Maria Carolina Amezcua Vesely, Andrea Iseppon, Leonie Brockmann, Hao Xu, Noah W Palm, Marcel R de Zoete, Paula Licona-Limón, Ricardo S Paiva, Travers Ching, Casey Weaver, Xiaoyuan Zi, Xinghua Pan, Rong Fan, Lana X Garmire, Matthew J Cotton, Yotam Drier, Bradley Bernstein, Jens Geginat, Brigitta Stockinger, Enric Esplugues, Samuel Huber, Richard A Flavell Nature. 2015 Jul

• A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.
  Pelczar, P., M. Witkowski, L. G. Perez, J. Kempski, A. G. Hammel, L. Brockmann, D. Kleinschmidt, S. Wende, C. Haueis, T. Bedke, M. Witkowski, S. Krasemann, S. Steurer, C. J. Booth, P. Busch, A. Konig, U. Rauch, D. Benten, J. R. Izbicki, T. Rosch, A. W. Lohse, T. Strowig, N. Gagliani*, R. A. Flavell*, and S. Huber*. *contributed equally
  Science. 2016
  
  
• Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.
  Gagliani, N., M. C. Amezcua Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell*. *contributed equally
  Nature. 2015
  
  
• Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
  Gagliani N*, Magnani CF*, Huber S*, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell RA, Roncarolo MG. *contributed equally
  Nat Med. 2013
  
  
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
  Huber S*, Gagliani N*, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA *contributed equally
  Nature. 2012
  
  
• Control of TH17 cells occurs in the small intestine.
  Esplugues E*, Huber S*, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor WJr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. *contributed equally
  Nature. 2011
  
  
• Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
  Huber S*, Gagliani N*, Esplugues E*, O'Connor WJr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. *contributed equally
  Immunity. 2011

• Studium der Medizin an der Universität Göttingen
• Promotion (Dr. med.) am European Neuroscience Institute Göttingen
• Assistenzarzt in der III. Medizinischen Klinik, UKE
• Forschungsstipendium der DFG am MRC National Institute for Medical Research, London
• Facharzt für Innere Medizin und Nephrologie
• Projektleiter des DFG geförderten Emmy-Noether-Froschungsgruppe “Innate Lymphoid Cells in Renal Inflammation”
• Habilitation und Lehrberechtigung in der Inneren Medizin und Nephrologie
• Oberarzt in der III. Medizinischen Klinik, UKE

• Walter-Hörl-Stipendium der Deutschen Nierenstiftung (2013)
• Hans-U.-Zollinger-Forschungspreis der DGfN (2018)

• Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis.

  Constantin Rickassel, Ann-Christin Gnirck, Nikhat Shaikh, Virginia Adamiak, Alex Waterhölter, Yakup Tanriver, Katrin Neumann, Tobias B Huber, Georg Gasteiger, Ulf Panzer, Jan-Eric Turner J Immunol. 2022 Apr

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• Tissue-specific therapy in immune-mediated kidney diseases: new ARGuments for targeting the IL-23/IL-17 axis.

  Krebs CF, Tuner JE, Riedel JH, Panzer UJ Clin Invest. 2021 Jun

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

  Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U B Enk, Fabian Hausmann, Alina Borchers , Milagros N Wong, Hans-Joachim Paust , Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher , Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze Zur-Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer , Nicola Gagliani, Christian F Krebs.Sci Immunol. 2021 Feb

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• Innate Lymphoid Cells in Renal Inflammation.

  Becker M, Gnirck AC, Turner JEFront Immunol. 2020 Jan

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

• T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus. 

  Düster M, Becker M, Gnirck AC, Wunderlich M, Panzer U, Turner JEEur J Immunol. 2018 Aug

• Innate lymphoid cells in autoimmunity and chronic inflammatory diseases. 

  Xiong T, Turner JESemin Immunopathol. 2018 Jul

• Innate Lymphoid Cells – Key players in tissue-specific immunity. 

  Turner JE, Gasteiger GSemin Immunopathol. 2018 Jul

• Tissue-Resident Lymphocytes in the Kidney.

  Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer J Am Soc Nephrol. 2018 Feb

• Natural killers: the bad guys in fibrosis? 

  Turner JEKidney Int. 2017 Jul

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.
  Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B
  J Exp Med. 2013
  
  
• Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
  Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B
  Nat Immunol. 2013
  
  
• IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.
  Turner JE, Stockinger B, Helmby H
  PLoS Pathog. 2013
  
  
• IL-17A production by renal gd T cells promotes kidney injury in crescentic GN.
  Turner JE, Krebs C, Tittel AP, Paust HJ, Meyer-Schwesinger C, Bennstein SB, Steinmetz OM, Prinz I, Magnus T, Korn T, Stahl RA, Kurts C, Panzer U
  J Am Soc Nephrol. 2012
  
  
• CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
  Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrucker HW, Tiegs G, Stahl RA, Panzer U
  J Am Soc Nephrol. 2010
  
  
• The many lives of IL-9: a question of survival?
  Wilhelm C, Turner JE, Van Snick J, Stockinger B
  Nat Immunol. 2012
  
  
• The Th17 immune response in renal inflammation.
  Turner JE, Paust HJ, Steinmetz OM, Panzer U
  Kidney Int. 2010

• Studium der Medizin und Physik an der Universität Göttingen
• Promotion (Dr. med.) im Institut für Immunologie an der Universität Göttingen
• Assistenzarzt und wissenschaftlicher Mitarbeiter in der Inneren Medizin an der Medizinischen Hochschule Hannover (MHH)
• Postdoc-Mitarbeiter am The Walter and Eliza Hall Institute for Medical Research (WEHI), Melbourne, Australia
• Habilitation in experimenteller Nephrologie
• Facharzt für Innere Medizin
• Arbeitsgruppenleiter in der Klinik für Nephrologie und Klinischer Immunologie, RWTH Aachen
• Heisenberg Stipendium der DFG
• C3 Professur für Molekulare Immunologie an der Universität Bonn
• Direktor des Instituts für Experimentelle Immunologie, Universität Bonn
• Co-Sprecher des SFB 704
• Co-Sprecher des SFB TR57 “Organ-Fibrosis” am Standort Bonn
• Gewähltes Mitglied der Deutsche Akademie der Naturforscher Leopoldina
• Gewähltes Mitglied im Fachkollegium Medizin der DFG
• Sprecher der Internationalen Graduiertenschule GRK 2168 Bo&MeRanG
  (Bonn & Melbourne Research and Graduate training Group)
• Vorstandsmitglied des DFG Excellence Cluster “ImmunoSensation²”, Bonn

• Sir Hans Krebs Preis für medizinischen Grundlagenwissenschaft (1999)
• Hans-U.-Zollinger-Preis der Deutschen Gesellschaft für Nephrologie (2010)
• Gottfried-Wilhelm-Leibniz-Preis der DFG (2012)

• Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs

  Janine Becker-Gotot, Mirjam Meissner, Vadim Kotov, Blanca Jurado-Mestre, Andrea Maione, Andreas Pannek, Thilo Albert, Chrystel Flores, Frank A Schildberg, Paul A Gleeson, Birgit M Reipert, Johannes Oldenburg, Christian KurtsJ Clin Invest. 2022 Nov

• Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.

  Nina Kessler, Susanne F Viehmann, Calvin Krollmann, Karola Mai, Katharina M Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M C Böhner, Dennis Huugen, Carina C de Oliveira Mann, Simon Otten, Stefanie A I Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A Lyons, Peter Boor, Angela Rösen-Wolff, Lino L Teichmann, Peter Heeringa, Christian Kurts, Natalio GarbiJ Exp Med. 2022 Oct

• Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.

  Ermanila Dhana, Daniela Klaus, Alexander Böhner, Florian Schmidt, Sibylle von Vietinghoff, Peter Boor, Sonja Djudjaj, Christian KurtsJ Immunol Methods. 2022 Aug

• Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice.

  Alexander M C Böhner, Alice M Jacob, Christoph Heuser, Natascha E Stumpf, Alexander Effland, Zeinab Abdullah, Catherine Meyer-Schwesiger, Sibylle von Vietinghoff, Christian Kurts J Am Soc Nephrol. 2021 Oct

• Drawing a single-cell landscape of the human kidney in (pseudo)-space and time.

  Krebs CF, Schlitzer A, Kurts C.Kidney Int. 2020 May

• A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation.

  Jobin K, Stumpf NE, Schwab S, Eichler M, Neubert P, Rauh M, Adamowski M, Babyak O, Hinze D, Sivalingam S, Weisheit C, Hochheiser K, Schmidt SV, Meissner M, Garbi N, Abdullah Z, Wenzel U, Hölzel M, Jantsch J, Kurts C Sci Transl Med. 2020 Mar

• Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.

  Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ. Kidney Int. 2019 Aug

• Protecting the kidney against autoimmunity and inflammation.

  Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Salt, inflammation, IL-17 and hypertension.

  Wenzel UO, Bode M, Kurts C, Ehmke H.Br J Pharmacol. 2018 May

• Pro-longed IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells.

  Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges JF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine AK, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.Cell Rep. 2017 Oct

• Fully automated evaluation of total glomerular num-ber and capillary tuft size in murine nephritic kidneys using lightsheet microscopy.

  Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Matthias GunzerJ Am Soc Nephrol. 2017 Feb

• Inhibitor of NFκB Kinase Subunit 2 Blockade Hinders the Initiation but Ag-gravates the Progression of crescentic glomerulonephritis.

  Gotot J, Piotrowski E, Otte MS, Tittel AP, Guo L, Yao C, Ziegelbauer K, Panzer U, Garbi N, Kurts C, Thaiss FJ Am Soc Nephrol. 2016 Jul

• A NLRP3-specific inflammasome inhibitor potently attenuates crystal-induced kidney fibrosis in vivo.

  Ludwig-Portugall I,*, Bartok E,* Dhana E, Evers BDG, Primiano MJ, Hall PJ, Franklin BS, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.Kidney Int 2016

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

  Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts CJ Am Soc Nephrol. 2016 Nov

• Immune Mechanisms in Arterial Hypertension

  Wenzel U, Turner J, Krebs C, Kurts C, Harrison D, Ehmke H J Am Soc Nephrol. 2016 Mar

• Assessing core competences of medical students with a test for flight school applicants
  Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
  BMC Med Educ. 2019
  
  
• Perceived strain of undergraduate medical students during a simulated first day of residency.
  Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
  BMC Med Educ. 2018
  
  
• Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
  Vogel D, Meyer M, Harendza S
  BMC Med Educ. 2018
  
  
• Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
  Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
  GMS J Med Educ. 2017
  
  
• Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
  Seeliger H, Harendza S
  BMC Med Educ. 2017
  
  
• Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
  Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S (2017).
  BMC Med Educ. 2017
  
  
• Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
  Dybowski C, Sehner S, Harendza S (2017).
  BMC Med Educ. 2017
  
  
• Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
  Prediger S, Harendza S (2016).
  GMS J Med Educ. 2016
  
  
• Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
  Dybowski C, Kriston L, Harendza S (2016).
  BMC Med Educ. 2016
  
  
• Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
  Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S (2015)
  Patient Educ Couns. 2015

• Studium der Medizin an der Universität Tübingen
• Promotion (Dr. med.) an der Universität Tübingen
• Arzt im Praktikum im Krankenhaus Siloah, Pforzheim
• Assistenzarzt am Institut für Pathologie an der Universität Tübingen
• Buswell Fellowship und Juniorprofessur in der medizinischen Abteilung, SUNY Buffalo, NY, USA
• Assistenzarzt in der Inneren Medizin an der Universität Freiburg
• Habilitation in der Inneren Medizin an der Universität Freiburg
• Gastwissenschaftler in der Abteilung für Nephrologie an der University of Washington, Seattle, USA
• Außerordentliche Professur der Medizin am Universitätsklinikum Frankfurt am Main
• Professur und Klinikleitung der III. Medizinische Klinik, UKE
• Seniorprofessur an der medizinischen Fakultät an der Universität Hamburg

• Franz-Volhard-Medaille der Deutschen Gesellschaft für Nephrologie (2017)

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses.

  Kluger MA, Nosko A, Ramcke T, Goerke B, Meyer MC, Wegscheid C, Luig M, Tiegs G, Stahl RA, Steinmetz OM.Clin Exp Immunol. 2017 Apr

• T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN. 

  Nosko A, Kluger MA, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OMJ Am Soc Nephrol. 2017 Jan

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• RORγt+Foxp3+ cells are an independent bifunctional regulatory T cell lineage and mediate crescentic GN.

  Kluger MA, Meyer MC, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2016 Feb

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
  Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
  J Am Soc Nephrol. 2015

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
  Meyer-Schwesinger C, Lambeau G, Stahl RA
  N Engl J Med. 2015

• Studium der Medizin an der Universität Hamburg

• Aufbaustudium „Molekularbiologie“ am Zentrum für Molekulare Neurobiologie Hamburg

• Promotion (Dr. med.) am Institut für Biochemie und Molekulare Biologie, UKE

• Förderung der Werner Otto Stiftung

• Gerok Position in der Klinischen Forschergruppe 228 “Immunopathogenesis and Therapy of Glomerulonephritis”

• Co-Antragsteller für Projekt 6 der KFO 228 “Immunopathogenesis and Therapy of Glomerulonephritis”

• Teilprojektleiter für Projekt B1 des SFB 1191 „Immunvermittelte glomeruläre Erkrankungen - Grundlagen und klinische Auswirkungen„

• Facharzt für Nephrologie und Innere Medizin

• Habilitation in Nephrologie und Innere Medizin

• Else Kröner Exzellenzstipendium

• Oberarzt in der III. Medizinische Klinik, UKE

• Heisenberg-Programm der Deutschen Forschungsgemeinschaft

   

• Leistungsstipendium von der Universität Hamburg (2004)
• „Best abstracts“ von dem XLVII ERA-EDTA Kongress (2010)
• Heinrich Nether Promotionspreis für Molekulare Biologie (2010)
• „Best oral presentations“ Deutschen Gesellschaft für Nephrologie Kongress (2012)
• Nils-Alwall-Preis der Deutschen Gesellschaft für Nephrologie (2016)
• Teacher of the Year 2018

• Pathogenicity of Human Anti-PLA 2 R1 Antibodies in Minipigs: A Pilot Study.

  Linda Reinhard, Thorsten Wiech, Aline Reitmeier, Moritz Lassé, Maya Machalitza, Asmus Heumann, Nicoletta Ferru, Desiree Loreth, Marie-Luise Schröder, Arvid Hutzfeldt, Felix R Stahl, Sven Peine, Hermann-Josef Gröne, Catherine Meyer-Schwesinger, Markus M Rinschen, Rolf A K Stahl, Elion HoxhaJ Am Soc Nephrol. 2023 Mar

• False positivity for PLA2R1 antibody measured by ELISA in a nephrotic patient with no membranous nephropathy.

  Elion Hoxha, Linda Reinhard, Thomas Castedello, Jan U BeckerKidney Int. 2023 Feb

• Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy.

  Thorsten Wiech, Linda Reinhard, Sonia Wulf, Alfio Edoardo Giuffrida, Elisa Longhitano, Rosario Caruso, Hermann-Josef Gröne, Rolf A K Stahl, Peter F Zipfel, Judith Kikhney, Annette Moter, Elion Hoxha, Domenico SantoroLancet. 2022 Nov

• Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy.

  Linda Reinhard, Maya Machalitza, Thorsten Wiech, Hermann-Josef Gröne, Moritz Lassé, Markus M Rinschen, Nicoletta Ferru, Jan Hinrich Bräsen, Friederike Drömann, Peter Maria Rob, Sanjeev Sethi, Elion Hoxha, Rolf A K StahlJ Am Soc Nephrol. 2022 Oct

• Membranous nephropathy: new pathogenic mechanisms and their clinical implications.

  Elion Hoxha, Linda Reinhard, Rolf A K StahlNat Rev Nephrol. 2022 Apr

• Perspectives in membranous nephropathy

  Tomas NM, Huber TB, Hoxha E.  Cell Tissue Res. 2021 Apr

• Rituximab Induces Complete Remission of Proteinuria in a Patient With Minimal Change Disease and No Detectable B Cells

  Webendörfer M, Reinhard L, Stahl RAK, Wiech T, Mittrücker HW, Harendza S, Hoxha E.Front Immunol. 2021 Feb

• A New Chemiluminescence Immunoassay for Phospholipase A2 Receptor 1 Autoantibodies Allows Early Identification of Autoantibody Recurrence in Patients With Membranous Nephropathy.

  Elion Hoxha, Rolf A K Stahl, Linda Reinhard, Alexander Kühnl, Wolfgang Schlumberger, Cornelia DähnrichKidney Int. Rep. 2021 Jan

• Is primary membranous nephropathy a complement mediated disease?

  Linda Reinhard, Rolf A K Stahl, Elion HoxhaMol Immunol. 2020 Dec

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.

  Jingyuan Xie, Lili Liu, Nikol Mladkova, [...] Elion Hoxha, Rolf A K Stahl, [...] Robert Kleta, Nan Chen, Krzysztof KirylukNat Commun. 2020 Mar

• Clinical Relevance of Domain-Specific Phospholipase A2 Receptor 1 Antibody Levels in Patients with Membranous Nephropathy.

  Linda Reinhard, Gunther Zahner, Stephan Menzel, Friedrich Koch-Nolt, Rolf A K Stahl, Elion HoxhaJ Am Soc Nephrol. 2020 Jan

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody negative patients with membranous nephropathy.
  Hoxha E, Harendza S, Pinnschmidt HO, Tomas NM, Helmchen U, Panzer U, Stahl RA.
  Nephrol Dial Transplant. 2015

• CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
  Brix SR, Stege G, Disteldorf E, Hoxha E, Krebs C, Krohn S, Otto B, Klätschke K, Herden E, Heymann F, Lira SA, Tacke F, Wolf G, Busch M, Jabs WJ, Özcan F, Keller F, Beige J, Wagner K, Helmchen U, Noriega M, Wiech T, Panzer U, Stahl RA
  J Am Soc Nephrol. 2015

• PLA2R antibody levels and clinical outcome in patients with membranous nephropathy and non-nephrotic range proteinuria under treatment with inhibitors of the renin-angiotensin system.
  Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RAK.
  PLoS One. 2014

• Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: a systematic review.
  Kronbichler A, Kerschbaum J, Fernandez-Fresnedo G, Hoxha E, Kurschat CE, Busch M, Bruchfeld A, Mayer G, Rudnicki M.
  Am J Nephrol. 2014

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014

• M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy.
  Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RA
  Clin J Am Soc Nephrol. 2014

• Phospholipase A2 Receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.
  Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA
  J Am Soc Nephrol. 2014

• Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy.
  Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W.
  Clin Chim Acta. 2013

• Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.
  Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen U, Stahl RAK.
  Kidney Int. 2012

• Renal IL-17 expression in human ANCA-associated glomerulonephritis.
  Velden J, Paust HJ, Hoxha E, Turner JE, Steinmetz OM, Wolf G, Jabs WJ, Özcan F, Beige J, Heering PJ, Schröder S, Kneißler U, Disteldorf E, Mittrücker HW, Stahl RA, Helmchen U, Panzer U.
  Am J Physiol Renal Physiol. 2012

• An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
  Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA
  Nephrol Dial Transplant. 2011

• Rituximab in adult patients with immunosuppressive-dependent minimal change disease.
  Hoxha E, Stahl RAK, Harendza S.
  Clin Nephrol. 2011

• Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
  Meyer-Schwesinger C, Sievert H, Meyer TN, Hoxha E, Sachs M, Klupp E-M, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl RAK.
  Am J Pathol. 2011

• Posttranscriptional regulation of the p85a adapter subunit of Phosphatidylinositol 3-kinase in human leukemia cells.
  Hoffmann BT, Hoxha E, Mohr E, Schulz K, Jücker M.
  Leuk Lymphoma. 2011

• PLA2R Autoantibodies and recurrent membranous nephropathy after transplantation.
  Stahl RAK, Hoxha E, Fechner K.
  N Engl J Med. 2010

• Studium der Medizin an den Universitäten Freiburg, Wien und South Florida (USA)
• Promotion (Dr. med.) in Physiologie am Universitätsklinikum Freiburg, summa cum laude
• Assistenzarzt und Wissenschaftlicher Mitarbeiter in der Innere Medizin am Universitätsklinikum Freiburg
• Emmy Noether Program – Phase I/ Postdoc-Stipendiat, Immunologie & Pathologie, Washington University St. Louis, USA
• United states medical licensing examination (USMLE)
• Emmy Noether Programm – Phase II/ Arbeitsgruppenleiter an der Universität Freiburg
• Habilitation an der Universität Freiburg
• Facharzt für Innere Medizin und Facharzt für Nephrologie
• Oberarzt in der IV Medizinischen Klinik an der Universität Freiburg
• Assoziiertes Mitglied des BIOSS Excellence Clusters, Freiburg
• Heisenberg Stipendium an der Universität Freiburg
• W3-Heisenbergprofessur an der Universität Freiburg
• Co-Sprecher des Else Kröner-Fresenius Kolleg „NAKSYS“, Universität Freiburg
• Stellvertretender Leiter der IV. Medizinischen Klinik der Universität Freiburg
• Klinikdirektor der III. Medizinischen Klinik, UKE
• Sprecher des Else Kröner-Fresenius Kolleg “iPRIME”, UKE

DFG programs awarded:

• Emmy Noether Program – Phase I/ Postdoc-Stipendiat, Immunologie & Pathologie, Washington University St. Louis, USA (2003-2006)
• Emmy Noether Programm – Phase II/ Arbeitsgruppenleiter an der Universität Freiburg (2006-2011)
• Heisenberg Stipendium an der Universität Freiburg (2011-2013)
• W3-Heisenbergprofessur an der Universität Freiburg (2013-2017)

Andere:

• “Young Nephrologist Award” der Deutschen Gesellschaft für Nephrologie (2002)
• Carl-Ludwig-Preis der Deutschen Gesellschaft für Nephrologie (2004)
• Projektleiter der SGBM Graduate School, Freiburg (seit 2006)
• Mitglied der Deutschen und Amerikanischen Gesellschaft für Nephrologie (seit 2007)
• Assoziiertes Mitglied des BIOSS Excellence Clusters, Freiburg (seit 2008)
• Hans-U.-Zollinger-Forschungspreis der Deutschen Gesellschaft für Nephrologie (2009)
• Franz-Volhard-Preis der Deutschen Gesellschaft für Nephrologie (2010)
• „Young Investigator Award” der American Society of Nephrology und der American Heart Association (2012)
• Gewähltes Mitglied der American Society for Clinical Investigation (2014)
• ERC Consolidator Grant (2014)
• Co-Sprecher des Else Kröner-Fresenius Kolleg „NAKSYS“, Universität Freiburg (2017)
• Sprecher des Else Kröner-Fresenius Kolleg "iPRIME”, UKE (2018)

• A slit-diaphragm-associated protein network for dynamic control of renal filtration.

  Maciej K Kocylowski, Hande Aypek, Wolfgang Bildl, Martin Helmstädter, Philipp Trachte, Bernhard Dumoulin, Sina Wittösch, Lukas Kühne, Ute Aukschun, Carolin Teetzen, Oliver Kretz, Botond Gaal, Akos Kulik, Corinne Antignac, Geraldine Mollet, Anna Köttgen, Burulca Göcmen, Jochen Schwenk, Uwe Schulte, Tobias B Huber, Bernd Fakler, Florian Grahammer Nat Commun. 2022 Oct

• Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice

  Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.Kidney Int. 2022 Sep

• Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy

  Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F. J Clin Invest. 2022 May

• Molecular consequences of SARS-CoV-2 liver tropism

  Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab. 2022 Mar

• IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases

  Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf PanzerJASN 2021 Dec

• Perspectives in membranous nephropathy

  Tomas NM, Huber TB, Hoxha E.  Cell Tissue Res. 2021 Apr

• ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage

  Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. J Am Soc Nephrol. 2021 Mar

• SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance

  Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstädter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C.  J Am Soc Nephrol. 2021 Mar

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• Podocytes maintain high basal levels of autophagy independent of mtor signaling.

  Tillmann Bork, Wei Liang, Kosuke Yamahara, Philipp Lee, Zhejia Tian, Shuya Liu, Christoph Schell, Kathrin Thedieck, Bjoern Hartleben, Ketan Patel , Pierre-Louis Tharaux, Olivia Lenoir, Tobias B HuberAutophagy. 2020 Nov

• The proteomic landscape of small urinary extracellular vesicles during kidney transplantation

  Braun F, Rinschen M, Buchner D, Bohl K, Plagmann I, Bachurski D, Richard Späth M, Antczak P, Göbel H, Klein C, Lackmann JW, Kretz O, Puelles VG, Wahba R, Hallek M, Schermer B, Benzing T, Huber TB, Beyer A, Stippel D, Kurschat CE, Müller RU.  J Extracell Vesicles. 2020 Oct

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• SARS-CoV-2 renal tropism associates with acute kidney injury

  Braun F, Luetgehetmann M, Pferfferle S, Wong M, Carsten A, Lindenmeyer M, Noerz, D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schroeder AS, Edler C, Aepfelbacher M, Puelles V, Huber TB.The Lancet. 2020 Aug

• Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria.

  Sachs W, Sachs M, Krüger E, Zielinski S, Kretz, Huber TB, Baranowsky A, Westermann LM, Volontolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C.J Am Soc Nephrol. 2020 Aug

• Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.

  Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A.Nat Cell Biol. 2020 Jul

• A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier.

  Liang W, Yamahara K, Hernando-Erhard C, Lagies S, Wanner N, Liang H, Schell C, Kammerer B, Huber TB, Bork T.Kidney Int. 2020 Jun

• Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.

  Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC.Cell. 2020 May

• Multi-organ and renal tropism of SARS-CoV-2

  Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Nicola Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Stefan Kluge S, Pueschel K, Aepfelbacher M, Huber TBNew England Journal of Medicine. 2020 May

• COVID-19-associated nephritis: early warning for disease severity and complications?

  Gross O, Moerer O, Weber M, Huber TB, Scheithauer SThe Lancet. Published Online 2020 May

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

  Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.Kidney Int. 2020 May* contributed equally

• Cellular and Molecular Probing of Intact Human Organs.

  Zhao S, Todorov MI, Cai R, -Maskari RA, Steinke H, Kemter E, Mai H, Rong Z, Warmer M, Stanic K, Schoppe O, Paetzold JC, Gesierich B, Wong MN, Huber TB, Duering M, Bruns OT, Menze B, Lipfert J, Puelles VG, Wolf E, Bechmann I, Ertürk A.Cell. 2020 Feb

• Renal clearance of polymeric nanoparticles by mimicry of glycan surface of viruses.

  Wyss PP, Lamichhane SP, Abed A, Vonwil D, Kretz O, Huber TB, Sarem M, Shastri VP. Biomaterials. 2020 Feb

• Podocytes maintain high basal levels of autophagy independent of mtor signaling.

  Bork T, Liang W, Yamahara K, Lee P, Tian Z, Liu S, Schell C, Thedieck K, Hartleben B, Patel K, Tharaux PL, Lenoir O, Huber TB. Autophagy. 2019 Dec

• Primary decidual zone formation requires Scribble for pregnancy success in mice.

  Yuan J, Aikawa S, Deng W, Bartos A, Walz G, Grahammer F, Huber TB, Sun X, Dey SK. Nat Commun. 2019 Nov

• mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

  Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF. JCI Insight. 2019 Sep

• Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.

  Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ. Kidney Int. 2019 Aug

• Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.

  Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TBCell Rep. 2019 Apr

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

  Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber TJ Am Soc Nephrol.. 2019 Jan

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.

  Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. Dev Cell. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

  Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. Cell Rep. 2018 May

• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
  Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles V, Rahman R, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek M, Romano T, Moritz K, Boerries M, Busch H, Bonn S, Little M, Bechtel-Walz W, Huber T
  J Am Soc Nephrol.. 2019 Jan.

• A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.
  Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. 
  Cell Rep. 2018 May

• ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.
  Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. 
  Dev Cell. 2018 Dec

• The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.
  Schell C, Rogg M, Suhm M, Helmstadter M, Sellung D, Yasuda-Yamahara M, Kretz O, Kuttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, and Huber TB.
  Proc Natl Acad Sci U S A. 2017
  
  
• mTORC2 critically regulates renal potassium handling.
  Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, and Huber TB.
  J Clin Invest. 2016
  
  
• Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
  Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, and Pearce EL.
  Cell. 2016
  
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
  Godel M, Grahammer F, and Huber TB.
  N Engl J Med. 2015
  
  
• Calciphylaxis.
  Zhou Q, Neubauer J, Kern JS, Grotz W, Walz G, and Huber TB.
  Lancet. 2014
  
  
• mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
  Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, and Huber TB.
  Proc Natl Acad Sci U S A. 2014
  
  
• Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
  Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mor A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, and Huber TB.
  J Clin Invest. 2011
  
  
• Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
  Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, and Huber TB.
  J Clin Invest. 2010

• Studium der Medizin an der Universität Witten/Herdecke
• Promotion (Dr. med.) am Institut für Immunologie, Universität Witten/Herdecke; summa cum laude
• United states medical licensing examination (USMLE)
• Assistenzarzt in der III. Medizinische Klinik, UKE
• Gerok Position in der Klinischen Forschungsgruppe 228 “Immunopathogenesis and Therapy of Glomerulonephritis”
• Postdoctoral fellowship am Institut für Molekulare und Zelluläre Pharmakologie, Universität Nizza / Sophia Antipolis, Frankreich
• Projektleiter der Emmy Noether Forschungsgruppe “Molecular Mechanisms of Membranous Nephropathy”

• Dr.-Martini-Preis der Dr.-Martini-Stiftung in Hamburg (2017)

• Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice.

  Nicola M Tomas, Silke Dehde, Catherine Meyer-Schwesinger, Ming Huang, Irm Hermans-Borgmeyer, Johanna Maybaum, Renke Lucas, Jennie L von der Heide, Oliver Kretz, Sarah M S Köllner, Larissa Seifert, Tobias B Huber, Gunther Zahner Kidney int. 2023 Feb

• The classical pathway triggers pathogenic complement activation in membranous nephropathy.

  Larissa Seifert, Gunther Zahner, Catherine Meyer-Schwesinger, Naemi Hickstein, Silke Dehde, Sonia Wulf, Sarah M S Köllner, Renke Lucas, Dominik Kylies, Sarah Froembling, Stephanie Zielinski, Oliver Kretz, Anna Borodovsky, Sergey Biniaminov, Yanyan Wang, Hong Cheng, Friedrich Koch-Nolte, Peter F Zipfel, Helmut Hopfer, Victor G Puelles, Ulf Panzer, Tobias B Huber, Thorsten Wiech, Nicola M TomasNat Commun. 2023 Jan

• Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice

  Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.Kidney Int. 2022 Sep

• Across scales: novel insights into kidney health and disease by structural biology.

  Nicola M Tomas, Simon A Mortensen, Matthias Wilmanns, Tobias B Huber Kidney Int. 2021 Apr

• Perspectives in membranous nephropathy

  Tomas NM, Huber TB, Hoxha E.  Cell Tissue Res. 2021 Apr

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

  Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.Kidney Int. 2020 May* contributed equally

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients.

  Catherine Meyer-Schwesinger, Nicola M Tomas, Silke Dehde, Larissa Seifert, Irm Hermans-Borgmeyer, Thorsten Wiech, Friedrich Koch-Nolte, Tobias B Huber, Gunther ZahnerKidney Int. 2020 May

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014

• Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin.
  Tomas, NM, Masur, K, Piecha, JC, Niggemann, B, Zanker, KS
  BMC Res Notes. 2012

• Studium der Chemie an den Universitäten Karlsruhe und Freiburg
• PhD in Strukturbiologie an der Universität Basel, Schweiz
• Postdoc an der Universität von Kalifornien, Los Angeles, USA
• Postdoc am EMBL, Struktur- und Computerbiologie, Heidelberg
• Leiter der Hamburger Gruppe des European Molecular Biology Laboratory (EMBL Hamburg)
• Leitender Wissenschaftler und Mitglied des Direktoriums am EMBL
• Habilitation an der Universität Basel, Schweiz
• Professor am Universitätsklinikum Hamburg-Eppendorf (UKE)
• Gründungsmitglied und wissenschaftlicher Leiter des Zentrums für Struktur und Systembiologie (CSSB)

• DFG Postdoctoral Fellowship
• EMBO Postdoctoral Fellowship
• Ehrendoktor, University of Oulu, Finland
• Gewähltes Mitglied der Akademie der nationalen Wissenschaften „Leopoldina“

Prof. Dr. Dr. h.c. Wilmanns hat nicht an der ersten Förderperiode teilgenommen.

• Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment. 
  Chatziefthimiou SD, Hornburg P, Sauer F, Mueller S, Ugurlar D, Xu ER, Wilmanns M
  PLoS One. 2019
  
  
• Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. 
  Pogenberg V, Ballesteros-Álvarez J, Schober R, Sigvaldadóttir I, Obarska-Kosinska A, Milewski M, Schindl R, Ögmundsdóttir MH, Steingrímsson E, Wilmanns M.
  Nucleic Acids Res. 2020
  
  
• Model-based local density sharpening of cryo-EM maps.
  Jakobi AJ, Wilmanns M, Sachse C.
  Elife. 2017
• In cellulo serial crystallography of alcohol oxidase crystals inside yeast cells.
  Jakobi AJ, Passon DM, Knoops K, Stellato F, Liang M, White TA, Seine T, Messerschmidt M, Chapman HN, Wilmanns M.
  IUCrJ. 2016
  
  
• Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties.
  Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M.
  PLoS Biol. 2012
  
  
• Fast-folding alpha-helices as reversible strain absorbers in the muscle protein myomesin.
  Berkemeier F, Bertz M, Xiao S, Pinotsis N, Wilmanns M, Gräter F, Rief M.
  Proc Natl Acad Sci U S A. 2011
  
  
• Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
  Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR.
  Circ Res. 2011
• Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.
  Sauer F, Vahokoski J, Song YH, Wilmanns M.
  EMBO Rep. 2010
  
  
• The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk.
  Bertz M, Wilmanns M, Rief M.
  Proc Natl Acad Sci U S A. 2009
  
  
• Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin.
  Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M.
  EMBO J. 2008
  
  
• Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. 
  Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M.
  Nature. 2006

• Studium der Medizin an der Universität Freiburg
• Promotion (Dr. med) an der Universität Freiburg und der Harvard Medical School, Boston, USA; summa cum laude
• Post-Doc-Stipendiatin am department of nephrology an der University of California, San Diego
• Wissenschaftliche Mitarbeiterin in der III. Medizinischen Klinik, UKE
• Habilitation in Experimenteller Medizin an der Universität Hamburg
• Heisenberg Stipendium
• W3 Heisenberg Professur Institut für Zelluläre und Integrative Physiologie, UKE Hamburg

• Dr. Martinipreis, UKE Hamburg-Eppendorf

• Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice

  Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.Kidney Int. 2022 Sep

• Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8 + T Cells

  Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz OM, Diehl L, Tiegs G, Neumann K.Cells. 2022 Apr

• ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage

  Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. J Am Soc Nephrol. 2021 Mar

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria.

  Sachs W, Sachs M, Krüger E, Zielinski S, Kretz, Huber TB, Baranowsky A, Westermann LM, Volontolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C.J Am Soc Nephrol. 2020 Aug

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

  Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.Kidney Int. 2020 May* contributed equally

• B6.Rag1 Knockout Mice Generated at the Jackson Laboratory in 2009 Show a Robust Wild-Type Hypertensive Phenotype in Response to Ang II (Angiotensin II).

  Seniuk A, Thiele JL, Stubbe A, Oser P, Rosendahl A, Bode M, Meyer-Schwesinger C, Wenzel UO, Ehmke H.Hypertension. 2020 Apr

• The Ubiquitin Proteasome System in Kidney Physiology and Disease.

  Meyer-Schwesinger CNat Rev Nephrol. 2019 Apr

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• Thrombospondin Type 1 Domain-Containing 7A (THSD7A) Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.

  Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger CJ Am Soc Nephrol. 2019 Apr

• Endogenous IL-22 is dispensable for tissue protection in experimental glomerulonephritis.

  Gnirck AC, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld JC, Huber S, Panzer U, Turner JEAm J Physiol Renal Physiol. 2019 Apr

• Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.

  Reinicke, AT, Laban, K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch CP, Duncan KE, Saftig P, Rischen MM, Morellini F, Meyer-Schwesinger CProc Natl Acad Sci U S A. 2019 Mar

• Protecting the kidney against autoimmunity and inflammation.

  Christian Kurts, Catherine Meyer-SchwesingerNat Rev Nephrol. 2018 Dec

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• IL-33-mediated expansion of type 2 innate lymphoid cells protects from progressive glomerulosclerosis

  Riedel JH, Becker M, Kopp K, Düster M, Brix SR, Meyer-Schwesinger C, Kluth LA, Gnirck AC, Attar M, Krohn S, Fehse B, Stahl RA, Panzer U, Turner JEJ Am Soc Nephrol. 2017 Jul

• Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

  Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• The Role of Renal Progenitors in Renal Regeneration

  Meyer-Schwesinger C Nephron. 2016

• Stat3 programs Th17-specific regulatory T cells to control GN.

  Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RAK, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun

• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
  Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
  Kidney Int. 2016
  
  
• The Role of Renal Progenitors in Renal Regeneration
  Meyer-Schwesinger C
  Nephron. 2016
  
  
• MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype.
  Kietzmann L*, Guhr SS*, Meyer TN, Ni L, Sachs M, Panzer U, Stahl RA, Saleem MA, Kerjaschki D, Gebeshuber CA* and Meyer-Schwesinger C*. *contributed equally
  J Am Soc Nephrol. 2015
  
  
• Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy
  Tomas, NM*, Beck, LH*, Jr., Meyer-Schwesinger, C, Seitz-Polski, B, Ma, H, Zahner, G, Dolla, G, Hoxha, E, Helmchen, U, Dabert-Gay, AS, Debayle, D, Merchant, M, Klein, J, Salant, DJ, Stahl, RA, Lambeau, G
  N Engl J Med. 2014
  
  
• UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
  Lohmann F, Sachs M, Meyer TN, Sievert H, Lindenmeyer MT, Wiech T, Cohen CD, Balabanov S, Stahl RAK, Meyer-Schwesinger C
  Biochim Biophys Acta. 2014
  
  
• Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases.
  Beeken M*, Lindenmeyer MT*, Blattner SM*, Radón V*, Oh J, Meyer TN, Hildebrand D, Schlüter H, Reinicke AT, Knop JH, Vivekanandan-Giri A, Münster S, Sachs M, Wiech T, Pennathur S, Cohen CD, Kretzler M, Stahl RAK, Meyer-Schwesinger C. *contributed equally
  J Am Soc Nephrol. 2014
  
  
• Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.
  Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C*, Engel DR*. *contributed equally
  Cell. 2014
  
  
• The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation.
  Guhr SS, Sachs M, Wegner A, Becker JU, Meyer TN, Kietzmann L, Schlossarek S, Carrier L, Braig M, Jat PS, Stahl RA, Meyer-Schwesinger C.
  Kidney Int. 2013

• Studium der Biologie an den Universitäten in Lehigh und Wesleyan, USA
• Bachelor of Arts in Biologie an der Universität Wesleyan, USA
• Studium der Medizin an der Universität Hamburg und Tübingen
• Promotion (Dr. med.) an der Universität Tübingen
• Studium der Molekularen Biologie an der Universität Hamburg
• Habilitation und venia legendi in Immunologie und Molekulare Biologie, UKE
• Forschungsaufenthalt im The Jackson Lab, Bar Harbor, ME
• Forschungsaufenthalt an der University of California in San Francisco, CA
• Professur für Immunologie and Molekulare Biologie, Universität Hamburg
• Forschungsaufenthalt am DNAX Research Institute, Palo Alto, CA
• Forschungsaufenthalt im The Jackson Lab, Bar Harbor, ME
• Stellvertretender Direktor am Institut für Immunologie, UKE
• Forschungsaufenthalt an der Université Rouen, France

• Martini-Preis (1990)
• Preis der Werner-Otto-Stiftung (1999)
• Preis für Mentorship der Claussen-Simon Stiftung (2009)

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

  Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.Kidney Int. 2020 May* contributed equally

• Purine Release, Metabolism, and Signaling in the Inflammatory Response.

  Linden J, Koch-Nolte F, Dahl G.Annu Rev Immunol. 2019 Jan

• T RM maintenance is regulated by tissue damage via P2RX7.

  Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW.Sci Immunol. 2018 Dec

• CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

  Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.Front Immunol. 2018 Nov

• Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

  Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.Methods Mol Biol. 2018 Aug

• Modulating ion channel function with antibodies and nanobodies.

  Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.Curr Opin Immunol. 2018 Jun

• Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

  Menzel S, Schwarz N, Haag F, Koch-Nolte F.Front Pharmacol. 2018 Mar

• Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. 

  Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte FSci Transl Med. 2016 Nov

• Trm maintenance is regulated by tissue damage via P2RX7.
  Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW
  Sci Immunol. 2018
  
  
• Modulating ion channel function with antibodies and nanobodies.
  Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.
  Curr Opin Immunol. 2018
  
  
• A cDNA immunization strategy to generate nanobodies against membrane proteins in native conformation.
  Eden T, Menzel S, Wesolowski J, Bergmann P, Nissen M, Dubberke G, Seyfried F, Albrecht B, Haag F, Koch-Nolte F.
  Front Immunol. 2018
  
  
• Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
  Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F
  Sci Rep. 2017
  
  
• NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
  Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F
  J Immunol. 2009
  
  
• NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
  Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
  Immunity. 2003

• Diploma in Molecular Medicine, University of Freiburg
• PhD in Molecular Medicine (summa cum laude), University of Freiburg
• Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg, Germany, Prof. Dr. Tobias B. Huber
• Laboratory head, III. Medical Department, University Medical Center Hamburg Eppendorf (UKE), Prof. Dr. Tobias B. Huber

• PhD Fellowship of the Spemann Graduate School of Biology and Medicine
• Rainer-Greger Prize for PhD thesis in Nephrology

•  mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
  Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF.
  JCI Insight. 2019 Sep 19;4(18):e99271.

• From podocyte biology to novel cures for glomerular disease.
  Torban E, Braun F, Wanner N, Takano T, Goodyer PR, Lennon R, Ronco P, Cybulsky AV, Huber TB.
  Kidney Int. 2019 Oct;96(4):850-861.

• DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
  Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB.
  J Am Soc Nephrol. 2019 Jan;30(1):63-78.

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II-induced hypertension.
  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust HJ, Huber TB, Stahl RAK, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UO. 
  Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1526-F1535.

• Gone but not forgotten: resolution of childhood kidney disease and the risk of end-stage kidney disease in adults.
  Wyatt CM, Wanner N.
  Kidney Int. 2018 Jun;93(6):1260-1262.

• New Insights into Podocyte Biology in Glomerular Health and Disease.
  Assady S, Wanner N, Skorecki KL, Huber TB. 
  J Am Soc Nephrol. 2017 Jun;28(6):1707-1715.

• Epigenetics of kidney disease.
  Wanner N, Bechtel-Walz W. 
  Cell Tissue Res. 2017 Jul;369(1):75-92. doi: 10.1007/s00441-017-2588-x.

• Targeting mTOR Signaling Can Prevent the Progression of FSGS.
  Zschiedrich S, Bork T, Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB.
  J Am Soc Nephrol. 2017 Jul;28(7):2144-2157.

• mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells.
  Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F. 
  J Am Soc Nephrol. 2017 Jan;28(1):230-241.

• Studium der Medizin an der Universität Hamburg
• Promotion (Dr. med.) in der Medizinischen Kernklinik am UKE
• Assistenzarzt am Institut für Pathologie in Freiburg
• Weiterbildung in Nierenpathologie am Institut für Pathologie in Basel
• Facharzt in Pathologie
• Habilitation in Pathologie an der Universität Freiburg
• Oberarzt am Institut für Pathologie am UKE
• W2 Professur am Institut für Pathologie am UKE

• Michael J. Mihatsch & Dusan Ferluga Award der Europäischen Gesellschaft für Pathologie

• ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage

  Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. J Am Soc Nephrol. 2021 Mar

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• Multi-organ and renal tropism of SARS-CoV-2

  Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Nicola Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Stefan Kluge S, Pueschel K, Aepfelbacher M, Huber TBNew England Journal of Medicine. 2020 May

• A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

  Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.Kidney Int. 2020 May* contributed equally

• CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

  Zipfel PF, Wiech T, Stea ED, Skerka C.J Am Soc Nephrol. 2020 Feb

• Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

  Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel & Christine SkerkaNat Commun. 2019 Jul

• Transcriptional and Clonal Characterization of Cytotoxic T cells in Crescentic Glomerulonephritis.

  Anne Mueller, Yu Zhao, Hakan Cicek, Hans-Joachim Paust, Amirrtavarshni Sivayoganathan, Alexandra Linke, Claudia Wegscheid, Thorsten Wiech, Tobias B Huber, Catherine Meyer-Schwesinger, Stefan Bonn, Immo Prinz, Ulf Panzer, Gisa Tiegs, Christian F Krebs, Katrin NeumannAm Soc Nephrol. 2023 Mar

• Development and validation of a renal risk score in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, Jabs W, Özcan F, Wendt R, Hausberg M, Sellin L, Panzer U, Huber T, Waldherr R, Hopfer H, Stahl R, Wiech TKidney Int. 2018 Dec

• Potential role for urine PCR in the diagnosis of Whipple's disease.

  Moter A, Janneck M, Wolters M, Iking-Konert C, Wiessner A, Loddenkemper C, Hartleben B, Lütgehetmann M, Schmidt J, Langbehn U, Janssen S, Geelhaar-Karsch A, Schneider T, Moos V, Rohde H, Kikhney J, Wiech T.Clin Infect Dis. 2018 Oct

• The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension

  Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel UAm J Physiol Renal Physiol. 2018 Sep

• Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis

  Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech THistopathology. 2018 Jun

• FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

  Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PFJ Immunol. 2018 Apr

• Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney

  Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger CKidney Int. 2018 Jan

• A Mechanism for Cancer-Associated Membranous Nephropathy. 

  Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RAN Engl J Med. 2016 May

• CXCR3+ regulatory T cells control TH1 responses in crescentic GN.
  Paust HJ, Riedel JH, Krebs CF, Turner JE, Brix SR, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein SB, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H-W, Steinmetz OM, Stahl RA, Panzer U.
  J Am Soc Nephrol. 2016
  

• FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.
  Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F.
  Nat Genet. 2012
  
  
• Histopathological patterns of nephrocalcinosis: a phosphate type can be distinguished from a calcium type.
  Wiech T, Hopfer H, Gaspert A, Banyai-Falger S, Hausberg M, Schröder J, Werner M, Mihatsch MJ.
  Nephrol Dial Transplant. 2012

• Studium der Biologie, Zellbiologie und Biochemie an der Universität Bremen
• Promotion (Dr. rer. nat.) an der Universität Bremen
• Postdoc im Labor für Immunregulation am National Institutes of Health, Bethesda, Maryland, USA, gefördert durch den Deutscher Akademischer Austauschdienst (DAAD)
• Visiting Associate im Labor für Immunregulation am National Institutes of Health, Bethesda, Maryland, USA
• Leiter einer Nachwuchsforschungsgruppe am Bernhard Nocht Institut für Tropenmedizin, Hamburg
• Adjunct Professor at the University of Hamburg
• Leiter der Abteilung Infektionsbiologie am Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, HKI, Jena
• Universitätsprofessor für Infektionsbiologie an der Friedrich Schiller Universität Jena
• Stellvertretender Direktor am Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie, HKI, Jena
• Sprecher der International Leibniz Research School for Microbial and Biomolecular Interactions
• Präsident des Europäischen Komplement Netzwerkes (2011- 2014)
• Beiratsmitglied der Internatioalen Complement Gesellschaft (ICS)
• Vorsitzender des Beutenberg Campus e.V, , Jena

• Thüringer Wissenschaftspreis (2004)
• Heinz Spitzbart Preis der Europäischen Vereinigung für Infektionskrankheiten in der Gynäkologie (2007)
• EFIS Lecture Award der Europäischen Vereinigung für Immunologischen Gesellschaften (2008)
• Wissenschaftspreis der Deutschen Gesellschaft für Hygiene und Mikrobiologie (2009)
• Galenus-von Pergamon-Preis in Grundlagenwissenschaft (2014)

• CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

  Zipfel PF, Wiech T, Stea ED, Skerka C.J Am Soc Nephrol. 2020 Feb

• Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

  Sarah Irmscher, Silke R. Brix, Svante L. H. Zipfel, Luke D. Halder, Sibel Mutlutürk, Sonia Wulf, Evaldas Girdauskas, Hermann Reichenspurner, Rolf A. K. Stahl, Berit Jungnickel, Thorsten Wiech, Peter F. Zipfel & Christine SkerkaNat Commun. 2019 Jul

• C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.

  Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C.Front Immunol. 2019 May

• ApoE attenuates unresolvable inflammation by complex formation with activated C1q.

  Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR* Nat Med. 2019 Mar *equal contribution

• C3 Glomerulopathy-Understanding a Rare Complement-Driven Renal Disease.

  Smith RJH, Appel G, Blom AM, Cook HT, D’Agati V, Fakhouri F, Véronique Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris J, Noris M, Pickering MC, Remuzzi G, Santiago Rodriguez de Córdoba S, Sethi S, Van der Vlag J, Zipfel PF, Nester CMNat Rev Nephrol. 2019 Mar

• The Case | A 78-year-old woman with acute kidney injury and hemolytic anemia.

  Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF Kidney Int. 2019 Feb

• FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

  Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PFJ Immunol. 2018 Apr

• FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. 

  Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka CJ Immunol. 2016 Jul

• The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension. 

  Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl RA, Ehmke H, Kurts C, Zipfel PF, Köhl J, Wenzel UOAm J Physiol Renal Physiol. 2016 Jun

• A 78-year old female with acute kidney injury and hemolytic anemia.
  Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF
  Kidney Int. 2019 Feb;95(2):473-474

• C1q-ApoE complexes control unresolvable inflammation.
  Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C*, Zipfel PF *, Skerka C*, Habenicht AJR*
  Nat Med. 2019 Mar;25(3):496-506 *equal contribution

• CFHR5-Hybrid proteins anchor properdin and activate complement at self-surfaces.
  Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF
  J Am Soc Nephrol, 27: 1413-1425

• Complement factor H–related hybrid protein deregulates complement in dense deposit disease
  Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, Zipfel PF
  J Clin Invest 124:145–155

• Combined C3b and Factor B Autoantibodies and MPGN Type II.
  Chen C, Müller D, Rudolph B, Hartmann A, Kuwertz-Bröking E, Wu K, Kirschfink M, Skerka C, Zipfel PF
  N Engl J Med 365:2340-2342

• Complement Factor H binds malondialdehyde-epitopes and protects from oxidative stress.
  Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HPN , Charbel Issa P, Cano M, Brandstätter H, Tsimikas S , Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ
  Nature 478:76-81

• Medical degree (MD): Universidad Peruana Cayetano Heredia, Lima, Peru
• PhD in Anatomy, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia
• Postdoc at Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia
• Postdoc at Department of Nephrology and Immunology, University Hospital RWTH Aachen, Aachen, Germany
• Postdoc at III. Department of Medicine, Hamburg-Eppendorf Medical Center, Hamburg, Germany
• Group Leader at III. Department of Medicine, Hamburg-Eppendorf Medical Center, Hamburg, Germany
• Professor (W1) at Department of Medicine, Hamburg-Eppendorf Medical Center, Hamburg, Germany

• Monash University Deputy Dean Award for undergraduate medical teaching (Monash University)
• Anthony Koelmeyer International PhD Excellence Award (Monash University)
• National Health and Medical Research Council of Australia Early Career Fellowship (CJ Martin)
• Humboldt Foundation Research Fellowship
• German Society of Nephrology Research Award

• Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy

  Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F. J Clin Invest. 2022 May

• Molecular consequences of SARS-CoV-2 liver tropism

  Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab. 2022 Mar

• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

  Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF Sci Immunol. 2021 Feb

• The proteomic landscape of small urinary extracellular vesicles during kidney transplantation

  Braun F, Rinschen M, Buchner D, Bohl K, Plagmann I, Bachurski D, Richard Späth M, Antczak P, Göbel H, Klein C, Lackmann JW, Kretz O, Puelles VG, Wahba R, Hallek M, Schermer B, Benzing T, Huber TB, Beyer A, Stippel D, Kurschat CE, Müller RU.  J Extracell Vesicles. 2020 Oct

• Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.

  Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.Kidney Int. 2020 Sep

• SARS-CoV-2 renal tropism associates with acute kidney injury

  Braun F, Luetgehetmann M, Pferfferle S, Wong M, Carsten A, Lindenmeyer M, Noerz, D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schroeder AS, Edler C, Aepfelbacher M, Puelles V, Huber TB.The Lancet. 2020 Aug

• Multi-organ and renal tropism of SARS-CoV-2

  Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Nicola Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Stefan Kluge S, Pueschel K, Aepfelbacher M, Huber TBNew England Journal of Medicine. 2020 May

• Podocyte number in children and adults: associations with glomerular size and numbers of other glomerular resident cells.
  Puelles VG, RN Douglas-Denton, LA Cullen-McEwen, J Li, MD Hughson, WE Hoy, PG Kerr and JF Bertram.
  J Am Soc Nephrol. 2015 Sep

• A novel 3D method for counting and sizing podocytes in whole glomeruli: validation in a model of podocyte depletion.
  Puelles VG*, JW van der Wolde*, KE Schulze, KM Short, MN Wong, JG Bensley, LA Cullen-McEwen, G Caruana, SN Hokke, J Li, SD Firth, IS Harper, DJ Nikolic-Paterson, and JF Bertram
  J Am Soc Nephrol. 2016 Oct
  *represents equal contributions

• Gli1+ mesenchymal stromal cells are key drivers of bone marrow fibrosis and important cellular therapeutic targets.
  Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.
  Cell Stem Cell. 2017 Jun

• New insights on glomerular hyperfiltration: a Japanese autopsy study.
  Kanzaki G*, Puelles VG*, LA Cullen-McEwen, WE Hoy, Y Okabayashi, N Tsuboi, A Shimizu, KM Denton, MD Hughson, T Yokoo, and JF Bertram
  JCI Insight. 2017 Oct
  *represents equal contributions

• Optical clearing in kidney reveals potassium-mediated tubule remodeling.
  Saritas T, Puelles VG, P Wellington, McCormick JA, and Ellison DH
  Cell Rep. 2018 Dec 4

• Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.
  Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Boehner A, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, and Moeller MJ
  Kidney Int. 2019 Aug

• The tetraspanin CD9 controls invasive migration and proliferation of parietal epithelial cells and glomerular disease progression.
  Lazareth H*, Henique C*, Lenoir O*, Puelles VG*, Flamant M, Bollée G, Camus M, Guyonnet L, Gaillard F, Chipont A, Robin B, Fabrega S, Camerer E, Dhaun N, Kretz O, Nochy D, Bruneval P, Mesnard L, Thervet E, Karras A, Boucheix C, Le Naour F, Rubinstein E, Alexandrou A, Moeller MJ, Bouzigues C, and Tharaux PL
  Nat Commun. 2019 Jul
  *represents equal contributions

• mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
  Puelles VG, JW van der Wolde;,N Wanner, M Scheppach, LA Cullen-McEwen, T Bork, MT Lindenmeyer, L Gernhold, MN Wong, F Braun, CD Cohen, MM Kett, C Kuppe, R Kramann, T Saritas, C van Roeyen, MJ Moeller, L Tribolet, R Rebello, YBY Sun, J Li, G Müller-Newen, MD Hughson, WE Hoy, F Person, T Wiech, SD Ricardo, PG Kerr, KM Denton, L Furic, TB Huber, DJ Nikolic-Paterson, and JF Bertram
  JCI Insight. 2019 Sep

• Cellular and Molecular Probing of Intact Human Organs.
  Zhao S, Todorov MI, Cai R, AI-Maskari R, Steinke H, Kemter E, Mai H, Rong Z, Warmer M, Aguilera KS, Schoppe O, Paetzold JC, Gesierich B, Wong MN, Huber TB, Düring M, Bruns OT, Menze B, Lipfert J, Puelles VG, Wolf E, Bechmann I, and Ertürk A
  Cell. 2020 Feb

• Multiorgan and renal tropism of SARS-CoV-2.
  Puelles VG*, Lütgehetmann M*, Lindenmeyer MT*, Sperhake JP*, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M and Huber TB
  N Engl J Med. 2020 May
  *represents equal contributions

• Studium der Humanmedizin an der Universität Frankfurt/Main
• Promotion (Dr. med.) an der Universität Frankfurt/Main
• Ärztin im Praktikum in der Nephrologie am Universitätsklinik Frankfurt/Main
• Postdoktorandenstipendium der DFG im Department of Nephrology, VAMC, University of California, San Francisco, USA
• Wissenschaftliche Mitarbeiterin in der III. Medizinische Klinik, UKE
• Master of Medical Education an der Universität Bern, Schweiz
• Fachärztin für Innere Medizin sowie für Nephrologie
• Habilitation in der Inneren Medizin, Universität Hamburg
• Oberärztin in der III. Medizinische Klinik, UKE
• Prodekanin für Lehre an der Medizinische Fakultät, Universität Hamburg (2006-2007)
• Universitätsprofessur (W3) für Innere Medizin/Ausbildungsforschung, III. Medizinische Klinik, UKE

• Carl Oelemannpreis (Promotionspreis des Landes Hessen) (1992)
• Janssen Cilag Förderpreis (2000)
• Posterpreis der Deutschen Gesellschaft für Innere Medizin (2005)
• Ars legendi-Preis des Stifterverbands für exzellente Hochschullehre (2006)
• Best Paper Award, III. Research in Medical Education Conference, Berlin (2013)
• Fellowship des Stifterverbands für Innovationen in der Hochschullehre (2015)
• Fellowship im Lehrlabor des Universitätskollegs QPL der Universität Hamburg (2018)
• Hamburger Lehrpreis (2019)

• Assessing core competences of medical students with a test for flight school applicants 
  Harendza S, Soll H, Prediger S, Kadmon M, Berberat PO, Oubaid V
  BMC Med Educ 2019

• Perceived strain of undergraduate medical students during a simulated first day of residency.
  Fürstenberg S, Prediger S, Kadmon M, Berberat PO, Harendza S
  BMC Med Educ 2018

• Verbal and non-verbal communication skills including empathy during history taking of undergraduate medical students.
  Vogel D, Meyer M, Harendza S
  BMC Med Educ 2018

• Implementation of a Clinical Reasoning Course in the Internal Medicine trimester of the final year of undergraduate medical training and its effect on students’ case presentation and differential diagnostic skills.
  Harendza S, Krenz I, Klinge A, Wendt U, Janneck M
  GMS J Med Educ 2017

• Is perfect good? – Dimensions of perfectionism in newly admitted medical students.
  Seeliger H, Harendza S
  BMC Med Educ 2017

• Competencies for first year residents – physicians’ views form medical schools with different undergraduate curricula.
  Fürstenberg S, Schick K, Deppermann J, Prediger S, Berberat PO, Kadmon M, Harendza S
  BMC Med Educ 2017

• Influence of motivation, self-efficacy and situational factors on the teaching quality of clinical educators.
  Dybowski C, Sehner S, Harendza S
  BMC Med Educ 2017

• Analysis of educational research at a medical faculty in Germany and suggestions for strategic development – a case study.
  Prediger S, Harendza S
  GMS J Med Educ 2016

• Psychometric properties of the newly developed Physician Teaching Self-Efficacy Questionnaire (PTSQ).
  Dybowski C, Kriston L, Harendza S
  BMC Med Educ 2016

• Translating medical documents into plain language enhances communication skills in medical students – A pilot study.
  Bittner A, Jonietz A, Bittner J, Beickert L, Harendza S
  Patient Educ Couns 2015