Publikationen
Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.
Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE.
Kidney Int. 2020 Sep
Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells.
Melderis S, Hagenstein J, Warkotsch MT, Dang J, Herrnstadt GR, Niehus CB, Neumann K, Panzer U, Berasain C, Avila MA, Tharaux PL, Tiegs G, Steinmetz OM.
J Am Soc Nephrol. 2020 Sep
SARS-CoV-2 renal tropism associates with acute kidney injury
Braun F, Luetgehetmann M, Pferfferle S, Wong M, Carsten A, Lindenmeyer M, Noerz, D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schroeder AS, Edler C, Aepfelbacher M, Puelles V, Huber TB.
The Lancet. 2020 Aug
Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease.
Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.
Sci Immunol. 2020 Aug
Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria.
Sachs W, Sachs M, Krüger E, Zielinski S, Kretz, Huber TB, Baranowsky A, Westermann LM, Volontolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C.
J Am Soc Nephrol. 2020 Aug
Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 Immunity.
Adrian Schreiber, Anthony Rousselle, Jan Klocke, Sebastian Bachmann, Suncica Popovic, Julia Bontscho, Kai M Schmidt-Ott, Volker Siffrin, Uwe Jerke, Muhammad Imtiaz Ashraf, Ulf Panzer, Ralph Kettritz
J Am Soc Nephrol. 2020 Jul
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.
Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A.
Nat Cell Biol. 2020 Jul
Kidney dendritic cells: fundamental biology and functional roles in health and disease.
Kurts C, Ginhoux F, Panzer U
Nat Rev Nephrol. 2020 Jul
A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier.
Liang W, Yamahara K, Hernando-Erhard C, Lagies S, Wanner N, Liang H, Schell C, Kammerer B, Huber TB, Bork T.
Kidney Int. 2020 Jun
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC.
Cell. 2020 May
Multi-organ and renal tropism of SARS-CoV-2
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Nicola Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Stefan Kluge S, Pueschel K, Aepfelbacher M, Huber TB
New England Journal of Medicine. 2020 May
Drawing a single-cell landscape of the human kidney in (pseudo)-space and time.
Krebs CF, Schlitzer A, Kurts C.
Kidney Int. 2020 May
COVID-19-associated nephritis: early warning for disease severity and complications?
Gross O, Moerer O, Weber M, Huber TB, Scheithauer S
The Lancet. Published Online 2020 May
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer.
Laura Garcia Perez, Jan Kempski, Heather M McGee, Penelope Pelzcar, Theodora Agalioti, Anastasios Giannou, Leonie Konczalla, Leonie Brockmann, Ramez Wahib, Hao Xu, Maria Carolina Amezcua Vesely, Shiwa Soukou, Babett Steglich, Tanja Bedke, Carolin Manthey, Oliver Seiz, Björn-Philipp Diercks, Stylianos Gnafakis, Andreas H Guse, Daniel Perez, Jakob R Izbicki, Nicola Gagliani, Richard A Flavell, Samuel Huber
Nat Commun. 2020 May
A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients
Meyer-Schwesinger C*, Tomas NM*, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G.
Kidney Int. 2020 May
* contributed equally
A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients.
Catherine Meyer-Schwesinger, Nicola M Tomas, Silke Dehde, Larissa Seifert, Irm Hermans-Borgmeyer, Thorsten Wiech, Friedrich Koch-Nolte, Tobias B Huber, Gunther Zahner
Kidney Int. 2020 May
B6.Rag1 Knockout Mice Generated at the Jackson Laboratory in 2009 Show a Robust Wild-Type Hypertensive Phenotype in Response to Ang II (Angiotensin II).
Seniuk A, Thiele JL, Stubbe A, Oser P, Rosendahl A, Bode M, Meyer-Schwesinger C, Wenzel UO, Ehmke H.
Hypertension. 2020 Apr
A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation.
Jobin K, Stumpf NE, Schwab S, Eichler M, Neubert P, Rauh M, Adamowski M, Babyak O, Hinze D, Sivalingam S, Weisheit C, Hochheiser K, Schmidt SV, Meissner M, Garbi N, Abdullah Z, Wenzel U, Hölzel M, Jantsch J, Kurts C
Sci Transl Med. 2020 Mar
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis.
Jingyuan Xie, Lili Liu, Nikol Mladkova, [...] Elion Hoxha, Rolf A K Stahl, [...] Robert Kleta, Nan Chen, Krzysztof Kiryluk
Nat Commun. 2020 Mar
CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.
Zipfel PF, Wiech T, Stea ED, Skerka C.
J Am Soc Nephrol. 2020 Feb